DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPINA12

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	413	Identity:	114/413 - (27%)
Similarity:	189/413 - (45%)	Gaps:	38/413 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLQGLNLAMANTLNYS--------KSPAGEAQFASQ-------LFGQLAKSQSGRNIVFSPSS 58
            ||.::||.....:..||.        |......:.|.|       |..:||....||||..||.|
Human    14 LLTVKGLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLS 78

  Fly    59 IRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRI 123
            |.|..::..|||:.||.||:|.|.......:.::.|....::    .|.....:|: ||...|.:
Human    79 ISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFHYII----HELTQKTQDL-KLSIGNTL 138

  Fly   124 FVTQRFKLTQTY-QDLVSKNFAAAAENV--NFTQKADTAKHINSWVEEQTHQQIKDLIAPESLDA 185
            |:.||.:..:.: :|  :||| .:||.:  ||.......|.||.::.::||.:|.:||  |::|.
Human   139 FIDQRLQPQRKFLED--AKNF-YSAETILTNFQNLEMAQKQINDFISQKTHGKINNLI--ENIDP 198

  Fly   186 DTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELP 250
            .|..:|.|.|:|:|.|:..|....|...||.......|.|..|.:...::.|...:|...::|:|
Human   199 GTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIP 263

  Fly   251 YTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEEL 315
            |. .:|..:.|||.|.: |..:|:.|.....:...:.|.||.|.|.:|:........|:..|..:
Human   264 YQ-KNITAIFILPDEGK-LKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYI 326

  Fly   316 GIKKLFSPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVFEFI 380
            |:.|:|....:|:.: .....|::.|..|||.::::|:||..:..|    ..::|.: |......
Human   327 GVSKIFEEHGDLTKI-APHRSLKVGEAVHKAELKMDERGTEGAAGT----GAQTLPM-ETPLVVK 385

  Fly   381 ADHPFFFAI--KDAQNTLFLGHV 401
            .|.|:...|  :...:.||||.:
Human   386 IDKPYLLLIYSEKIPSVLFLGKI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	107/381 (28%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	108/387 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010