DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpinh1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	377	Identity:	89/377 - (23%)
Similarity:	159/377 - (42%)	Gaps:	32/377 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKLDQLL 100
            |..|:..:||.|:..||:.||..:.:.|.|..||.:.:||.:.|..|..|.....||...|.:||
Mouse    50 AFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELL 114

  Fly   101 -------AKG-QWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKAD 157
                   |:. .|            |..:|::..........:.....:::......:||..|..
Mouse   115 RSLSNSTARNVTW------------KLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRS 167

  Fly   158 TAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRK 222
            ..:.||.|..:.|..::.::  .:.::....|:||||::||..|...|.........|:......
Mouse   168 ALQSINEWASQTTDGKLPEV--TKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYT 230

  Fly   223 VSVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQ 287
            |.|..|.:...:.:.:..:.|.::||:|........:|::|...:.|..:|:.|....|.....:
Mouse   231 VGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWMGK 295

  Fly   288 LRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLFSPG-ANLSSLYQGSEPLRISEVKHKAIIEVN 351
            ::::.|.:.|||...|....||..|..||:.:..... |:||.: .|.:.|.::.|.|....|.:
Mouse   296 MQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM-SGKKDLYLASVFHATAFEWD 359

  Fly   352 EKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIKDAQ--NTLFLGHV 401
            .:|.......:.:..:.|..:      |.|||||.|.::|.|  :.||:|.:
Mouse   360 TEGNPFDQDIYGREELRSPKL------FYADHPFIFLVRDNQSGSLLFIGRL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	89/375 (24%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	89/377 (24%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010