Protein Alignment Spn42De and SERPINA3

DIOPT Version :10

• Sequence 1: NP_610246.3
• Gene: Spn42De / 35602
• FlyBaseID: FBgn0033115
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 132/402 - (32%)
• Similarity: 191/402 - (47%)
• Gaps: 44/402 - (10%)

  Fly    15 LNLAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELK 79
            |.||.||           ..||..|:.||......:|::|||.||.|.||...|||..:|..|:.
Human    47 LGLASAN-----------VDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEIL 100

  Fly    80 LGL--GLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKN 142
            .||  .|....:.|:.:....||     ...:...|..:|...|.:||.::..|...:.:...:.
Human   101 KGLKFNLTETSEAEIHQSFQHLL-----RTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRL 160

  Fly   143 FAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPD 207
            :.:.|...:|...|...|.||.:|:..|..:|.|||  :.||:.|..:|||.|:|||.|:..|..
Human   161 YGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLI--KDLDSQTMMVLVNYIFFKAKWEMPFDP 223

  Fly   208 YATYASDFVNHGGRKVSVDTMSQE----DYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQG 268
            ..|:.|.|.....:.|.|..||..    .|||.   .||...||||.||| :...|.|||.:::
Human   224 QDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRD---EELSCTVVELKYTG-NASALFILPDQDK- 283

  Fly   269 LAIVEEKLMGIDLNEISSQLRRRKV-RVQLPKFKFEFDVPLQAALEELGIKKLFSPGANLSSLYQ 332
            :..||..|:...|......|..|:: .:.||||....|..|...|.:|||::.|:..|:||.: .
Human   284 MEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGI-T 347

  Fly   333 GSEPLRISEVKHKAIIEVNEKGTTASGATFIKVS-----VESLTIGEEVFEFIADHPFFFAI--K 390
            |:..|.:|:|.|||:::|.|:||.||.||.:|::     ||:.||    ..|  :.||...|  .
Human   348 GARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTI----VRF--NRPFLMIIVPT 406

  Fly   391 DAQNTLFLGHVS 402
            |.||..|:..|:
Human   407 DTQNIFFMSKVT 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	serpin42Dd-like_insects	30..403	CDD:381070	127/387 (33%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	132/402 (33%)
		RCL	369..394		11/28 (39%)
		O-glycosylated at one site	381..389		1/7 (14%)