DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINB7

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001035237.1	Gene:	SERPINB7 / 8710	HGNCID:	13902	Length:	380	Species:	Homo sapiens

Alignment Length:	366	Identity:	115/366 - (31%)
Similarity:	177/366 - (48%)	Gaps:	30/366 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NTVFSPASVQSALTLAFMGASG------------STAEELRNGLQLGPGDRHHIALNFGEFWRTS 85
            |..||..|:.:||.|..:||..            :||....|......|.:..:...|.:...:.
Human    27 NVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQSQLKRVFSDINASH 91

  Fly    86 CNYGDRGPVLKSVNRLYVNDSLELLTEFNEIAVDFFQSKAEATRFADS-EGATQLINDWVEQETE 149
            .:|.     |..||.|:.........::.|.|...:.:|.|...|.:. |...:.||.|||.||.
Human    92 KDYD-----LSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETH 151

  Fly   150 HKITNLLQSDAVNNETSALLINVLYFKGKWQKPFMPETTSIDHFHVDRDTHVQVNMMYQEDKFRF 214
            .||.|::....:::....:|:|.:|||||||..|....|...||...:.:...|.||:||.||..
Human   152 GKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNL 216

  Fly   215 AELPQLKARAVQLPYDYSNIHMLILLPNEVNGLQELEQQLNTVDLAD--IDAALTLQDVEIFLPR 277
            :.:.....:.::|.|: ..|:|.:|||.  |.|.|:|.:|...:|.:  ....:|.:.||:|.|:
Human   217 SVIEDPSMKILELRYN-GGINMYVLLPE--NDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQ 278

  Fly   278 MCIEYDVDLKQVLNQLGITEVFSD-KAKLDGLFTSQSGQK--ISAARHRGYIDVNEAGSEAAAVS 339
            ..||.:.::||.|..||:.::|.: ||.|.|:   .||.:  ||...|:.||:|.|.|:||.|.:
Human   279 FKIEKNYEMKQYLRALGLKDIFDESKADLSGI---ASGGRLYISRMMHKSYIEVTEEGTEATAAT 340

  Fly   340 FMKIVPMMLNMNKKLFKADHPFVFYIRNPQAVFFAGRFSNP 380
            ...||...|..: .||:|||||:|.||....:.|:|:.|.|
Human   341 GSNIVEKQLPQS-TLFRADHPFLFVIRKDDIILFSGKVSCP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	113/361 (31%)
SERPINB7	NP_001035237.1	serpinB7_megsin	1..380	CDD:381032	114/364 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930