DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINA6

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	370	Identity:	102/370 - (27%)
Similarity:	176/370 - (47%)	Gaps:	43/370 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQLGPGDRHHIALNFG-----EFWRTSCNYG 89
            |..|...||.|:..||.:..:|..|.|..:|..||.....:|....::.|     :.:..|
Human    59 PKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKS---- 119

  Fly    90 DRGPVLKSVNRLYVNDSLELLTEFNEIAVDFFQSKAEATRFADSEGATQLINDWVEQETEHKITN 154
            |....:...|.|:::.|||||..|:.....:::|:..|..|.|...|::.||.:|:.:|:.||.:
Human   120 DTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVD 184

  Fly   155 L---LQSDAVNNETSALLINVLYFKGKWQKPFMPETTSIDHFHVDRDTHVQVNMMYQEDKFRFAE 216
            |   |.|.|:     .:|:|.::|||.|.:||...:|..::|:||..|.|:|.||.|.....:..
Human   185 LFSGLDSPAI-----LVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLH 244

  Fly   217 LPQLKARAVQLPYDYSNIHMLILLPNEVNGLQELEQQLNTVDLA---DI----DAALTLQDVEIF 274
            ..:|..:.||:.| ..|..:..:||:        :.::|||..|   |.    .|.||...|:::
Human   245 DSELPCQLVQMNY-VGNGTVFFILPD--------KGKMNTVIAALSRDTINRWSAGLTSSQVDLY 300

  Fly   275 LPRMCIEYDVDLKQVLNQLGITEVFSDKAKLDGLFTSQSGQKISAARHRGYIDVNEAGSEAAAVS 339
            :|::.|....||..||.::||.::|:::|....: |..:..|.|...|:..:.:||.|.:.|..:
Human   301 IPKVTISGVYDLGDVLEEMGIADLFTNQANFSRI-TQDAQLKSSKVVHKAVLQLNEEGVDTAGST 364

  Fly   340 FMKIVPMMLNMNKK--LFKADHPFVFYIRN--PQAVFFAGRFSNP 380
                 .:.||:..|  :.:.:.||:..|.:  ..:..|..|..||
Human   365 -----GVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	99/365 (27%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	99/365 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020