DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and Serpind1

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	110/398 - (27%)
Similarity:	186/398 - (46%)	Gaps:	60/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QFARNLIDVITKDALQQSKDPHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQLGPGDRHHI 74
            :||.||..|:...|  .|.|   |...:|..:.:|:.:..:|..|.|.||:            |.
  Rat   112 KFAFNLYRVLKDQA--TSSD---NIFIAPVGISTAMGMISLGLRGETHEEV------------HS 159

  Fly    75 ALNFGEFWRTSCNY------------------GDRGPVLKSVNRLYVNDSLELLTEFNEIAVDFF 121
            .|:|.:|...|..|                  .:.|..|:|||.||:.....:..:|.....:|:
  Rat   160 VLHFKDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFY 224

  Fly   122 QSKAEATRFADSEGATQLINDWVEQETEH--KITNLLQSDAVNNETSA---LLINVLYFKGKWQK 181
            .::|:...|:|..        ::.:...|  |:|..|..:|:.|..||   :::|.:||||.|..
  Rat   225 FAEAQEADFSDPA--------FISKANSHILKLTKGLIKEALENTDSATQMMILNCIYFKGAWMN 281

  Fly   182 PFMPETTSIDHFHVDRDTHVQVNMMYQEDKFRFAELPQLKARAVQLPYDYSNIHMLILLPNEVNG 246
            .|..|.|...:|.::....|:|:||..:..|..|...:|....:||.| ...|.|||::|.:::|
  Rat   282 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVIPRKLSG 345

  Fly   247 LQELEQQLNTVDLADIDAALTLQDVEIFLPRMCIEYDVDLKQVLNQLGITEVFSDKAKLDGLFTS 311
            ::.||.||....:.....::|.:..|:.||:..:|.:.:|.:||..:|||::|:....:.|:
  Rat   346 MKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI--- 407

  Fly   312 QSGQK--ISAARHRGYIDVNEAGSEAAAVSFMKIVPMMLNMNKKLFKADHPFVF--YIRNPQAVF 372
             |.|:  |...:|:..|.|||.|::||||:.:..:|:...:.   |..|.||:|  |......:.
  Rat   408 -SDQRIIIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVR---FTVDRPFLFLVYEHRTSCLL 468

  Fly   373 FAGRFSNP 380
            |.||.:||
  Rat   469 FMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	107/393 (27%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	110/398 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020