DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINB6

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_011512974.1	Gene:	SERPINB6 / 5269	HGNCID:	8950	Length:	454	Species:	Homo sapiens

Alignment Length:	389	Identity:	126/389 - (32%)
Similarity:	206/389 - (52%)	Gaps:	32/389 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EGRNQFARNLIDVITKDALQQSKDPHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQL---- 66
            |....||.||:..:.||   .||    |..|||.|:..||.:.:|||.|:||.::...|..
Human    84 EANGTFALNLLKTLGKD---NSK----NVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSG 141

  Fly    67 GPGDRHH-IALNFGEFWRTSCNYGDRGPVLKSVNRLYVNDSLELLTEFNEIAVDFFQSKAEATRF 130
            |.||.|. ......|..:|...|     :|:..|||:...|.:.|:.|.:....|:|::.|...|
Human   142 GGGDIHQGFQSLLTEVNKTGTQY-----LLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDF 201

  Fly   131 ADS-EGATQLINDWVEQETEHKITNLLQSDAVNNETSALLINVLYFKGKWQKPFMPETTSIDHFH 194
            ..: |.:.:.||.||.::||.||..||...:|:..|..:|:|.:||:|.|.:.|..|.|....|.
Human   202 ISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFK 266

  Fly   195 VDRDTHVQVNMMYQEDKFRFAELPQLKARAVQLPYDYSNIHMLILLPNEVNGLQELEQQL---NT 256
            |.::....|.||:::..|:...:.::..:.:.|||....::|:|:||:|...|:.:|::|   ..
Human   267 VSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKF 331

  Fly   257 VDLADIDAALTLQDVEIFLPRMCIEYDVDLKQVLNQLGITEVFS-DKAKLDGLFTSQSGQKISAA 320
            |:...:| .:..::||:.|||..:|...|::.||..||:|:.|. .||...|:  ||:...:|..
Human   332 VEWTRLD-MMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGM--SQTDLSLSKV 393

  Fly   321 RHRGYIDVNEAGSEAAAVSFMKIVPMMLNMNKKL--FKADHPFVFYIRNPQ--AVFFAGRFSNP 380
            .|:.:::|||.|:||||.:   ...||:...:.:  |.|||||:|:|::.:  .:.|.||||:|
Human   394 VHKSFVEVNEEGTEAAAAT---AAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	121/383 (32%)
SERPINB6	XP_011512974.1	PAI-2	82..454	CDD:239013	125/387 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830