DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINF1

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	380	Identity:	92/380 - (24%)
Similarity:	170/380 - (44%)	Gaps:	53/380 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LQQSKDPHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQ---LGPGDRHHIALNFGEFWRTS 85
            ::.|..|..|.:.||.||.:||:...:||...|...:...|.   :...|.|      |.:....
Human    68 VRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIH------GTYKELL 126

  Fly    86 CNYGDRGPVLKSVNRLYVNDSLELLTEFNEIAVDFFQSKAEATRFADSEGATQL----INDWVEQ 146
            .........|||.:|:.....|.:.:.|  :|.   ..|:..||.....|..:|    ||:||:.
Human   127 DTVTAPQKNLKSASRIVFEKKLRIKSSF--VAP---LEKSYGTRPRVLTGNPRLDLQEINNWVQA 186

  Fly   147 ETEHKITNLLQSDAVNNETSALLINVLYFKGKWQKPFMPETTSIDHFHVDRDTHVQVNMMYQEDK 211
            :.:.|:..  .:..:.:|.|.||:.|.:|||:|...|....||::.|::|.:..|:|.|| .:.|
Human   187 QMKGKLAR--STKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMM-SDPK 248

  Fly   212 --FRFAELPQLKARAVQLPYDYSNIHMLILLPNEV-NGLQELEQQLNTVDLADIDAALTLQDVEI 273
              .|:.....|..:..|||.. .::.::..||.:| ..|..:|:.|.:..:.|||..|......:
Human   249 AVLRYGLDSDLSCKIAQLPLT-GSMSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVL 312

  Fly   274 FLPRMCIEYDVDLKQVLNQLGITEVFS--DKAKLDGLFTSQSGQKISAARHRGYIDVNEAGS--- 333
            .:|::.:.|:.::.:.|.::.:..:|.  |.:|:.|     ...|::...||...:.||.|:
Human   313 TVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITG-----KPIKLTQVEHRAGFEWNEDGAGTT 372

  Fly   334 -----EAAAVSFMKIVPMMLNMNKKLFKADHPFVFYIRNPQ--AVFFAGRFSNPK 381
                 :.|.::|    |:..::|:       ||:|.:|:..  |:.|.|:..:|:
Human   373 PSPGLQPAHLTF----PLDYHLNQ-------PFIFVLRDTDTGALLFIGKILDPR 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	91/374 (24%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	91/377 (24%)
		O-glycosylated at one site	371..383		1/11 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010