DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINA2

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_006211.2	Gene:	SERPINA2 / 390502	HGNCID:	8985	Length:	421	Species:	Homo sapiens

Alignment Length:	372	Identity:	97/372 - (26%)
Similarity:	173/372 - (46%)	Gaps:	53/372 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NTVFSPASVQSALTLAFMGASGSTAEELRNGLQLG----PGDRHHIALNFGEFWRTSCNYGDRGP 93
            |.:.:|.||..|..:..:|....|..|:..||.:.    |..:.|....               .
Human    76 NVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEAKIHECFQ---------------Q 125

  Fly    94 VLKSVNR------------LYVNDSLELLTEFNEIAVDFFQSKAEATRFADSEGATQLINDWVEQ 146
            ||::::|            |:||.|::|:..|.|.....:.|:|.:..|.|:|.|.:.||::||:
Human   126 VLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEAKEQINNYVEK 190

  Fly   147 ETEHKITNLLQSDAVNNETSALLINVLYFKGKWQKPFMPETTSIDHFHVDRDTHVQVNMMYQEDK 211
            .|..|:.:|::.  :..:||..|::.:.|.|||:..|..|...::.||||..|.::|.|:....:
Human   191 RTGRKVVDLVKH--LKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKTIIRVPMINHLGR 253

  Fly   212 FRFAELPQLKARAVQLPYDYSNIHMLILLPNEVNGLQELEQQLNTVDLADIDAALTLQDVEIFLP 276
            |......:|.:..:...| ..|.....:|| :...:.:||::|....|.:|..|..::.:.:..|
Human   254 FDIHRDRELSSWVLAQHY-VGNATAFFILP-DPKKMWQLEEKLTYSHLENIQRAFDIRSINLHFP 316

  Fly   277 RMCIEYDVDLKQVLNQLGITEVFSDKAKLDGLFTSQSGQKISAARHRGYIDVNEAGSEAAAV--- 338
            ::.|.....||:||..||||::||::|.|.|: :.::..|:|.|.|...:.::|.|:||...
Human   317 KLSISGTYKLKRVLRNLGITKIFSNEADLSGV-SQEAPLKLSKAVHVAVLTIDEKGTEATGAPHL 380

  Fly   339 ---SFMKIVPMMLNMNKKLFKADHPFVFYIRNPQAVF--FAGRFSNP 380
               ::.|...:|.|         .||:..|::....|  |.|:..||
Human   381 EEKAWSKYQTVMFN---------RPFLVIIKDDITNFPLFIGKVVNP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	95/367 (26%)
SERPINA2	NP_006211.2	SERPIN	62..418	CDD:214513	95/370 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010