DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPIND1

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	184/398 - (46%)	Gaps:	60/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QFARNLIDVITKDALQQSKDPHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQLGPGDRHHI 74
            :||.||..|: ||.:    :...|...:|..:.:|:.:..:|..|.|.|::            |.
Human   132 KFAFNLYRVL-KDQV----NTFDNIFIAPVGISTAMGMISLGLKGETHEQV------------HS 179

  Fly    75 ALNFGEFWRTSCNY------------------GDRGPVLKSVNRLYVNDSLELLTEFNEIAVDFF 121
            .|:|.:|...|..|                  .:.|..|:|||.||:.....:|.:|.....:::
Human   180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244

  Fly   122 QSKAEATRFADSEGATQLINDWVEQETEH--KITNLLQSDAVNN---ETSALLINVLYFKGKWQK 181
            .::|:...|:|..        ::.:...|  |:|..|..||:.|   .|..:::|.:||||.|..
Human   245 FAEAQIADFSDPA--------FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVN 301

  Fly   182 PFMPETTSIDHFHVDRDTHVQVNMMYQEDKFRFAELPQLKARAVQLPYDYSNIHMLILLPNEVNG 246
            .|..|.|...:|.::....|:|:||..:..|..|...:|....:||.| ...|.|||::|::::|
Human   302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPHKMSG 365

  Fly   247 LQELEQQLNTVDLADIDAALTLQDVEIFLPRMCIEYDVDLKQVLNQLGITEVFSDKAKLDGLFTS 311
            ::.||.||....:.....::|.:..|:.||:..:|.:.:|.:.|..:||..:|.....:.|:
Human   366 MKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI--- 427

  Fly   312 QSGQKIS--AARHRGYIDVNEAGSEAAAVSFMKIVPMMLNMNKKLFKADHPFVF--YIRNPQAVF 372
             |.|:|:  ..:|:|.|.|||.|::|..|:.:..:|:...:.   |..|.||:|  |......:.
Human   428 -SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVR---FTVDRPFLFLIYEHRTSCLL 488

  Fly   373 FAGRFSNP 380
            |.||.:||
Human   489 FMGRVANP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	102/393 (26%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	105/398 (26%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020