Protein Alignment Spn42Dc and SERPINB1

DIOPT Version :10

• Sequence 1: NP_610245.2
• Gene: Spn42Dc / 35600
• FlyBaseID: FBgn0033113
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 132/404 - (32%)
• Similarity: 205/404 - (50%)
• Gaps: 49/404 - (12%)

  Fly     1 MSEPQEGRNQFARNLIDVITKDALQQSKDPHINTVFSPASVQSALTLAFMGASGSTAEELRNGLQ 65
            |.:......:||.:|...::::      :|..|...||.|:.||:.:.|:|..|:||.:|.....
Human     1 MEQLSSANTRFALDLFLALSEN------NPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFH 59

  Fly    66 LGPGDRHHIALNFGEFWRTSCNYGDRGP--VLKSVNRLYVNDSLELLTEF----------NEIAV 118
            ....:..|     ..|...:.:...||.  :||..||||...:...|.||          :..:|
Human    60 FNTVEEVH-----SRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASV 119

  Fly   119 DFFQSKAEATRFADSEGATQLINDWVEQETEHKITNLLQSDAVNNETSALLINVLYFKGKWQKPF 183
            ||..:         ||.|.:.||.||:.:||.||..||.|..|:|.|..:|:|.:||||.|:..|
Human   120 DFQHA---------SEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKF 175

  Fly   184 MPETTSIDHFHVDRDTHVQVNMMYQEDKFRFAELPQLKARAVQLPYDYSNIHMLILLPNEV---- 244
            |.|.|:...|.:::.....|.||||:.||.:..:..||.|.::|||....:.|:||||:::
Human   176 MKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDES 240

  Fly   245 NGLQELEQQLNTVDLADIDAALTLQ--DVEIFLPRMCIEYDVDLKQVLNQLGITEVF-SDKAKLD 306
            .||:::|:||....|.:......|.  :|.:.|||..:|....|...|.:||:.::| |.||.|.
Human   241 TGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLS 305

  Fly   307 GLFTSQSGQK---ISAARHRGYIDVNEAGSEAAAVSFMKIVPMMLNMNKKLFKADHPFVFYIRNP 368
            |:    ||.:   ||...|:.:::|||.|:||||.: ..|....:.|.::.|.|||||:|:||:.
Human   306 GM----SGARDIFISKIVHKSFVEVNEEGTEAAAAT-AGIATFCMLMPEENFTADHPFLFFIRHN 365

  Fly   369 Q--AVFFAGRFSNP 380
            .  ::.|.||||:|
Human   366 SSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_610245.2	serpin42Dd-like_insects	7..380	CDD:381070	130/396 (33%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	131/402 (33%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		14/27 (52%)