DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dc and SERPINA12

DIOPT Version :9

Sequence 1:	NP_001246154.1	Gene:	Spn42Dc / 35600	FlyBaseID:	FBgn0033113	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	413	Identity:	100/413 - (24%)
Similarity:	197/413 - (47%)	Gaps:	67/413 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEPQEGRNQFARNLIDVITKDALQQSKD-------------PHINTVFSPASVQSALTLAFMGA 52
            :||.|..:.:.|       .|:..:|:.|             |..|...||.|:.:|.::..:||
Human    33 LSEVQGWKQRMA-------AKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGA 90

  Fly    53 SGSTAEELRNGL---QLGPGDRHH---------------IALNFGEFWRTSCNYGDRGPVLKSVN 99
            ..||.:|::.|.   ::...|.|.               :.|:.|                   |
Human    91 QDSTLDEIKQGFNFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIG-------------------N 136

  Fly   100 RLYVNDSLELLTEFNEIAVDFFQSKAEATRFADSEGATQLINDWVEQETEHKITNLLQSDAVNNE 164
            .|:::..|:...:|.|.|.:|:.::...|.|.:.|.|.:.|||::.|:|..||.||:::  ::..
Human   137 TLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLEMAQKQINDFISQKTHGKINNLIEN--IDPG 199

  Fly   165 TSALLINVLYFKGKWQKPFMPETTSIDHFHVDRDTHVQVNMMYQEDKFRFAELPQLKARAVQLPY 229
            |..||.|.::|:.:|:..|.|..|..:.|.:::::.|:|.||::...::.....:|....:::||
Human   200 TVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPY 264

  Fly   230 DYSNIHMLILLPNEVNGLQELEQQLNTVDLADIDAALTLQDVEIFLPRMCIEYDVDLKQVLNQLG 294
            . .||..:.:||:| ..|:.||:.|.....:.....|:.:.|::.:||:.:....|||:.|:.:|
Human   265 Q-KNITAIFILPDE-GKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIG 327

  Fly   295 ITEVFSDKAKLDGLFTSQSGQKISAARHRGYIDVNEAGSEAAAVSFMKIVPMMLNMNKKLFKADH 359
            ::::|.:...|..:...:| .|:..|.|:..:.::|.|:|.||.:..:.:||...:   :.|.|.
Human   328 VSKIFEEHGDLTKIAPHRS-LKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPL---VVKIDK 388

  Fly   360 PFVFYIRNPQ--AVFFAGRFSNP 380
            |::..|.:.:  :|.|.|:..||
Human   389 PYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dc	NP_001246154.1	SERPIN	7..377	CDD:238101	95/402 (24%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	95/404 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010