DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPINB11

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001357404.1	Gene:	SERPINB11 / 89778	HGNCID:	14221	Length:	392	Species:	Homo sapiens

Alignment Length:	386	Identity:	113/386 - (29%)
Similarity:	197/386 - (51%)	Gaps:	34/386 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGGL--------- 67
            :|.|.:...|...:.|.||.:|.||:..:.:|:.:|..  ..|.:::::.|.|...
Human    10 EFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGAR--GETEEQLEKVLHFSHTVDSLKPGFK 72

  Fly    68 ------EAQQVAESFGVVLKSYEQ----CQVLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEI 122
                  :|.::...|||......|    | .|.:||.||..|.:...:|:....|:.::::...:
Human    73 DSPKCSQAGRIHSEFGVEFSQINQPDSNC-TLSIANRLYGTKTMAFHQQYLSCSEKWYQARLQTV 136

  Fly   123 DF--GSEQAASIINKWVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREED 185
            ||  .:|:....||.|||::||..:.::.|...:...|.:.|||.|:|||:|...|..:||.:..
Human   137 DFEQSTEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIYFKGQWQNKFQVRETVKSP 201

  Fly   186 F-FGSDRPTRVRMMHVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDI 249
            | ....:...|.||:....|..|.:...:...|.:.|....|:||||||...:||..:||:|:..
Human   202 FQLSEGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVNNKLSMIILLPVGIANLKQIEKQLNSG 266

  Fly   250 SLEVVSSAMNL--EKVDVKIPSFTAEFQQELSQVLMLMGMNRIFSG-QAELGGMLQSEESLFVSQ 311
            :....:|:.|:  .:|:|.:|.|..|.:.||:.:|..:|:..:|:. :|:|.|| ...:.|::|:
Human   267 TFHEWTSSSNMMEREVEVHLPRFKLETKYELNSLLKSLGVTDLFNQVKADLSGM-SPTKGLYLSK 330

  Fly   312 IVHKAFIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIK-DNTHGLLFAG 371
            .:||::::::|.||||||||......:|:|.|    ..|.||.||.:.|: .:|:.:||.|
Human   331 AIHKSYLDVSEEGTEAAAATGDSIAVKSLPMR----AQFKANHPFLFFIRHTHTNTILFCG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	113/386 (29%)
SERPINB11	NP_001357404.1	ovalbumin_like	4..392	CDD:239014	113/386 (29%)
SERPINB11	NP_001357404.1	RCL. /evidence=ECO:0000250	341..365		12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930