Protein Alignment Spn42Db and SERPINH1

DIOPT Version :10

• Sequence 1: NP_610244.2
• Gene: Spn42Db / 35599
• FlyBaseID: FBgn0033112
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_001226.2
• Gene: SERPINH1 / 871
• HGNCID: 1546
• Length: 418
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 93/388 - (23%)
• Similarity: 163/388 - (42%)
• Gaps: 37/388 - (9%)

  Fly     5 EFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSA-TAKEMDEGLRFGGLE 68
            |.:.||   |..|:..:.:..|..||:.||:.:..|..::.:|   |.| ||.:....|....|.
Human    45 ERSAGL---AFSLYQAMAKDQAVENILVSPVVVASSLGLVSLG---GKATTASQAKAVLSAEQLR 103

  Fly    69 AQQVAESFGVVLKSYEQCQ----VLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQA 129
            .::|....|.:|:|.....    ..|:.:.||....:...:.|....:|.:..:..:|:|..:::
Human   104 DEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRS 168

  Fly   130 A-SIINKWVESQTNNLIKDIIGPRVLTKD----SRLCLVNGIHFKGEWSISFNEKETREEDFFGS 189
            | ..||:|....|:..:.::      |||    ....|||.:.||..|...|:.|......|..:
Human   169 ALQSINEWAAQTTDGKLPEV------TKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVT 227

  Fly   190 DRPT-RVRMMH--VCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISL 251
            ...| .|.|||  ...|::.......:...:.:.:...:|  |||:|.....|..|||.|:...|
Human   228 RSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSL--IILMPHHVEPLERLEKLLTKEQL 290

  Fly   252 EVVSSAMNLEKVDVKIPSFTAEFQQELSQVLMLMGMNR-IFSGQAELGGMLQSEESLFVSQIVHK 315
            ::....|..:.|.:.:|....|...:|.:.|..:|:.. |...:|:|..| ..::.|:::.:.|.
Human   291 KIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM-SGKKDLYLASVFHA 354

  Fly   316 AFIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDNTHG-LLFAGHFITTK 377
            ...|::..|.............||       ||:|:|:.||.:.::|...| |||.|..:..|
Human   355 TAFELDTDGNPFDQDIYGREELRS-------PKLFYADHPFIFLVRDTQSGSLLFIGRLVRPK 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	serpin42Da-like	9..372	CDD:381065	90/377 (24%)
SERPINH1	NP_001226.2	serpinH1_CBP1	36..417	CDD:381003	93/388 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	415..418