DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPINH1

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	388	Identity:	93/388 - (23%)
Similarity:	163/388 - (42%)	Gaps:	37/388 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSA-TAKEMDEGLRFGGLE 68
            |.:.||   |..|:..:.:..|..||:.||:.:..|..::.:|   |.| ||.:....|....|.
Human    45 ERSAGL---AFSLYQAMAKDQAVENILVSPVVVASSLGLVSLG---GKATTASQAKAVLSAEQLR 103

  Fly    69 AQQVAESFGVVLKSYEQCQ----VLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQA 129
            .::|....|.:|:|.....    ..|:.:.||....:...:.|....:|.:..:..:|:|..:::
Human   104 DEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRS 168

  Fly   130 A-SIINKWVESQTNNLIKDIIGPRVLTKD----SRLCLVNGIHFKGEWSISFNEKETREEDFFGS 189
            | ..||:|....|:..:.::      |||    ....|||.:.||..|...|:.|......|..:
Human   169 ALQSINEWAAQTTDGKLPEV------TKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVT 227

  Fly   190 DRPT-RVRMMH--VCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISL 251
            ...| .|.|||  ...|::.......:...:.:.:...:|  |||:|.....|..|||.|:...|
Human   228 RSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSL--IILMPHHVEPLERLEKLLTKEQL 290

  Fly   252 EVVSSAMNLEKVDVKIPSFTAEFQQELSQVLMLMGMNR-IFSGQAELGGMLQSEESLFVSQIVHK 315
            ::....|..:.|.:.:|....|...:|.:.|..:|:.. |...:|:|..| ..::.|:::.:.|.
Human   291 KIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM-SGKKDLYLASVFHA 354

  Fly   316 AFIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDNTHG-LLFAGHFITTK 377
            ...|::..|.............||       ||:|:|:.||.:.::|...| |||.|..:..|
Human   355 TAFELDTDGNPFDQDIYGREELRS-------PKLFYADHPFIFLVRDTQSGSLLFIGRLVRPK 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	89/375 (24%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	93/388 (24%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920