DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and Serpind1

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	93/372 - (25%)
Similarity:	163/372 - (43%)	Gaps:	47/372 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGG-------------------LE 68
            :|::..||..:|:.|..:..|:.:|..  ..|.:|:...|.|..                   |.
  Rat   124 QATSSDNIFIAPVGISTAMGMISLGLR--GETHEEVHSVLHFKDFVNASSKYEVTTIHNLFRKLT 186

  Fly    69 AQQVAESFGVVLKSYEQCQVLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQAASII 133
            .:....:||..|:|         .|.||:.|...:.|.|...:.:.:.::..|.||......|..
  Rat   187 HRLFRRNFGYTLQS---------VNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPAFISKA 242

  Fly   134 NKWVESQTNNLIKDIIGPRVLTKDS--RLCLVNGIHFKGEWSISFNEKETREEDFFGSDRP-TRV 195
            |..:...|..|||:.:.    ..||  ::.::|.|:|||.|...|..:.|...:|..::|. .:|
  Rat   243 NSHILKLTKGLIKEALE----NTDSATQMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVVKV 303

  Fly   196 RMMHVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISLEVVSSAMNL 260
            .||....||..|.....:...|::.|.. .::|:|::|.:.|.:.:||.:|:...:|....:|..
  Rat   304 SMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVIPRKLSGMKTLEAQLTPQVVERWQKSMTN 367

  Fly   261 EKVDVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQSEESLFVSQIVHKAFIEINEVGT 325
            ...:|.:|.|..|....|.:||..||:.::|:....:.|:  |::.:.:....|::.|.:||.||
  Rat   368 RTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI--SDQRIIIDLFKHQSTITVNEEGT 430

  Fly   326 EAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDN-THGLLFAG 371
            :|||.|.......|...|      |..:|||.:.:.:: |..|||.|
  Rat   431 QAAAVTTVGFMPLSTQVR------FTVDRPFLFLVYEHRTSCLLFMG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	93/372 (25%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	93/372 (25%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020