DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPING1

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_000053.2	Gene:	SERPING1 / 710	HGNCID:	1228	Length:	500	Species:	Homo sapiens

Alignment Length:	374	Identity:	93/374 - (24%)
Similarity:	159/374 - (42%)	Gaps:	51/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LEQFALCL-HDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGGLEAQQVA 73
            |..|:|.| |..........|:.:||.||......:.:|..|.:.|..|          ......
Human   146 LVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLE----------SILSYP 200

  Fly    74 ESFGVV---LKSYEQCQVLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQAASIINK 135
            :.|..|   ||.:....|..::. ::....|.:.:.|.:.....:.|.|..:...|:....:||.
Human   201 KDFTCVHQALKGFTTKGVTSVSQ-IFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINT 264

  Fly   136 WVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDFFGSDRPTRVRMMHV 200
            ||...|||.|..::..  |..|:||.|:|.|:...:|..:|:.|:||.|.|...:...:|.||:.
Human   265 WVAKNTNNKISRLLDS--LPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNS 327

  Fly   201 CENFFFAVLPMFEAT------ALRMNYSACNLAMIILLPDE-KSNLTSLEKKLSDISLEVVSSAM 258
            .:   :.|....:.|      .|::::   ||:::||:|.. |..|..:|:.||....:.:...:
Human   328 KK---YPVAHFIDQTLKAKVGQLQLSH---NLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKL 386

  Fly   259 NLEKVD---VKIPSFTAEFQQELSQVLMLMGMNRI----FSGQAELGGMLQSEESLFVSQIVHKA 316
            .:.|..   :.:|.......|:     ||..|.::    ||....|.| |..:..|.||.:.|:.
Human   387 EMSKFQPTLLTLPRIKVTTSQD-----MLSIMEKLEFFDFSYDLNLCG-LTEDPDLQVSAMQHQT 445

  Fly   317 FIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDNTH 365
            .:|:.|.|.||||| :|::..|::       .||...:||.:.:.|..|
Human   446 VLELTETGVEAAAA-SAISVARTL-------LVFEVQQPFLFVLWDQQH 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	92/372 (25%)
SERPING1	NP_000053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..118
		7 X 4 AA tandem repeats of [QE]-P-T-[TQ]	85..119
		C1_inh	145..495	CDD:239005	93/374 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010