DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPINA2

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_006211.2	Gene:	SERPINA2 / 390502	HGNCID:	8985	Length:	421	Species:	Homo sapiens

Alignment Length:	383	Identity:	109/383 - (28%)
Similarity:	189/383 - (49%)	Gaps:	29/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGGLE 68
            ::.:..:...|..|:..|...|...|::.:|.|:.::.|||.:||...:.|  |:.|||.....|
Human    51 QKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRT--EILEGLNVNLTE 113

  Fly    69 AQQ--VAESFGVVLKSYEQCQV-LKMANG--LYVMKGLQVDEQFGHILEQKFRSKPMEIDF-GSE 127
            ..:  :.|.|..||::..:... |::..|  |:|.|.:::.:.|....::.:.|:...|:| .:|
Human   114 TPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTE 178

  Fly   128 QAASIINKWVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDFFGSDRP 192
            :|...||.:||.:|...:.|::  :.|.||:.|.||:.|.|.|:|...|..:....|.|...|:.
Human   179 EAKEQINNYVEKRTGRKVVDLV--KHLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKT 241

  Fly   193 -TRVRMMHVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISLEVVSS 256
             .||.|::....|.........:..|..:|.. |.....:|||.| .:..||:||:...||.:..
Human   242 IIRVPMINHLGRFDIHRDRELSSWVLAQHYVG-NATAFFILPDPK-KMWQLEEKLTYSHLENIQR 304

  Fly   257 AMNLEKVDVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQSEESLFVSQIVHKAFIEIN 321
            |.::..:::..|..:.....:|.:||..:|:.:|||.:|:|.|:.| |..|.:|:.||.|.:.|:
Human   305 AFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQ-EAPLKLSKAVHVAVLTID 368

  Fly   322 EVGTEAAAA----TAAVATFRSMPARQGPPKVFHANRPFFYAIKDN-THGLLFAGHFI 374
            |.||||..|    ..|.:.::::        :|  ||||...|||: |:..||.|..:
Human   369 EKGTEATGAPHLEEKAWSKYQTV--------MF--NRPFLVIIKDDITNFPLFIGKVV 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	109/372 (29%)
SERPINA2	NP_006211.2	SERPIN	62..418	CDD:214513	108/372 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7631
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960