DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and Serpina1e

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_033273.1	Gene:	Serpina1e / 20704	MGIID:	891967	Length:	413	Species:	Mus musculus

Alignment Length:	397	Identity:	121/397 - (30%)
Similarity:	197/397 - (49%)	Gaps:	47/397 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KDE-----EFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEG 61
            ||:     |.|..|..||:.|:..|...|...||.:||:||..:.|||.:| |:|. |..::.||
Mouse    35 KDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLG-SKGD-THTQILEG 97

  Fly    62 LRFGGLEAQQ--VAESFGVVLKSYEQCQ---VLKMANGLYVMKGLQVDEQFGHILEQKFRSKPME 121
            |:|...:..:  :..||..:|::..:..   .|...|||:|...|::.|:|....:..::::...
Mouse    98 LQFNLTQTSEADIHNSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFS 162

  Fly   122 IDFG-SEQAASIINKWVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREED 185
            ::|. ||:|..:||.:||..|...|.:.:  :.|.:|:...|.|.|.|||:|...|:.:.|::.:
Mouse   163 VNFAESEEAKKVINDFVEKGTQGKIVEAV--KKLEQDTVFVLANYILFKGKWKKPFDPENTKQAE 225

  Fly   186 FFGSDRPT-RVRMM--------HVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTS 241
            |...:..| :|.||        |.|..        ..:..|.|:| |.|...:.||||: ..:..
Mouse   226 FHVDESTTVKVPMMTLSGMLDVHHCST--------LSSWVLLMDY-AGNATAVFLLPDD-GKMQH 280

  Fly   242 LEKKLSDISLEVVSS-AMNLEK--VDVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQS 303
            ||:.|:.   |::|. .:|..:  ..:.||..:......|..::..:|:.|||:..|:|.|:.:.
Mouse   281 LEQTLNK---ELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFNSGADLSGITEE 342

  Fly   304 EESLFVSQIVHKAFIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAI-KDNTHGL 367
            ...|.:||.||||.:.|:|.||||||||.....|.||      |.:.|.||||.:.| ::::...
Mouse   343 NAPLKLSQAVHKAVLTIDETGTEAAAATVLQGGFLSM------PPILHFNRPFLFIIFEEHSQSP 401

  Fly   368 LFAGHFI 374
            ||.|..:
Mouse   402 LFVGKVV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	116/379 (31%)
Serpina1e	NP_033273.1	SERPIN	53..410	CDD:214513	114/379 (30%)
Serpina1e	NP_033273.1	RCL	368..387		8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010