Protein Alignment Spn42Db and SERPINB1

DIOPT Version :10

• Sequence 1: NP_610244.2
• Gene: Spn42Db / 35599
• FlyBaseID: FBgn0033112
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 125/383 - (32%)
• Similarity: 198/383 - (51%)
• Gaps: 21/383 - (5%)

  Fly     4 EEFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGGL- 67
            |:.:....:|||.|...|...:...||..||.||..:.||:.:|| .|: ||.::.:...|..:
Human     2 EQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGT-RGN-TAAQLSKTFHFNTVE 64

  Fly    68 EAQQVAESFGVVLKSYEQCQVLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDF--GSEQAA 130
            |.....:|....:.......:||:||.||..|......:|....::.:.:....:||  .||.|.
Human    65 EVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDAR 129

  Fly   131 SIINKWVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDF--FGSDRPT 193
            ..||:||:.||...|.:::...::...::|.|||.|:|||.|...|.::.|....|  ...||.|
Human   130 KTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKT 194

  Fly   194 RVRMMHVCENFFFAVLPMFEATALRMNYSACNLAMIILLP----DEKSNLTSLEKKLSDISLEVV 254
             |:||:..:.|.:..:...:...|.:.|....|:|:||||    ||.:.|..:|::|:...|...
Human   195 -VKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEW 258

  Fly   255 SSAMNLE--KVDVKIPSFTAEFQQELSQVLMLMGMNRIF-SGQAELGGMLQSEESLFVSQIVHKA 316
            :...||:  :|:|.:|.|..|....|:..|..:|:..:| |.:|:|.|| .....:|:|:||||:
Human   259 TKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGM-SGARDIFISKIVHKS 322

  Fly   317 FIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDNTHG-LLFAGHF 373
            |:|:||.|||||||||.:|||..:.    |.:.|.|:.||.:.|:.|:.| :||.|.|
Human   323 FVEVNEEGTEAAAATAGIATFCMLM----PEENFTADHPFLFFIRHNSSGSILFLGRF 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	serpin42Da-like	9..372	CDD:381065	122/375 (33%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	125/383 (33%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		11/26 (42%)