DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and Serpind1

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	370	Identity:	90/370 - (24%)
Similarity:	163/370 - (44%)	Gaps:	43/370 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGG-------------------LE 68
            :|:...|:..:|:.|..:..|:.:|..  ..|.:|:...|.|..                   |.
Mouse   123 QATTSDNLFIAPVGISTAMGMISLGLR--GETHEEVHSVLHFRDFVNASSKYEVTTIHNLFRKLT 185

  Fly    69 AQQVAESFGVVLKSYEQCQVLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQAASII 133
            .:....:||..|:|         .||||:.|...:.|.|...:.:.:.::..|.:|......|..
Mouse   186 HRLFRRNFGYTLRS---------VNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPAFISKA 241

  Fly   134 NKWVESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDFFGSDRP-TRVRM 197
            |..:...|..|||:.:  ..:...:::.::|.|:|||.|...|..:.|...:|..::|. .:|.|
Mouse   242 NNHILKLTKGLIKEAL--ENIDPATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSM 304

  Fly   198 MHVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISLEVVSSAMNLEK 262
            |....||..|.....:...|::.|.. .::|:|::|.:.|.:.:||.:|:...:|....:|....
Mouse   305 MQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRT 368

  Fly   263 VDVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQSEESLFVSQIVHKAFIEINEVGTEA 327
            .:|.:|.|..|....|.:||..||:.::|:....:.|:  |::.:.:....|::.|.:||.||:|
Mouse   369 REVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI--SDQRIAIDLFKHQSTITVNEEGTQA 431

  Fly   328 AAATAAVATFRSMPARQGPPKVFHANRPFFYAIKDN-THGLLFAG 371
            ||.|.......|...|      |..:|||.:.:.:: |..|||.|
Mouse   432 AAVTTVGFMPLSTQVR------FTVDRPFLFLVYEHRTSCLLFMG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	90/370 (24%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	90/370 (24%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020