DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPINA12

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	384	Identity:	105/384 - (27%)
Similarity:	175/384 - (45%)	Gaps:	27/384 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKDEEFAQGLEQFALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFG 65
            |..:|.|:........|...|...:.|.||..|||||..:.:||.:|..:  :|..|:.:|..|.
Human    43 MAAKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQD--STLDEIKQGFNFR 105

  Fly    66 GLEAQQVAESFGVVLKSYEQ-CQVLKMA--NGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGS- 126
            .:..:.:.|.|..::....| .|.||::  |.|::.:.||...:|....:..:.::.:..:|.:
Human   106 KMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNL 170

  Fly   127 EQAASIINKWVESQT----NNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDFF 187
            |.|...||.::..:|    ||||::|....|      :.|.|.|.|:..|...|:...|:|||||
Human   171 EMAQKQINDFISQKTHGKINNLIENIDPGTV------MLLANYIFFRARWKHEFDPNVTKEEDFF 229

  Fly   188 -GSDRPTRVRMMHVCENFFFAVLPMFEATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISL 251
             ..:...:|.||.....:..........|.|.:.|.. |:..|.:|||| ..|..|||.|...:.
Human   230 LEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQK-NITAIFILPDE-GKLKHLEKGLQVDTF 292

  Fly   252 EVVSSAMNLEKVDVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQSEESLFVSQIVHKA 316
            ....:.::...|||.:|........:|.:.|..:|:::||....:| ..:....||.|.:.||||
Human   293 SRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDL-TKIAPHRSLKVGEAVHKA 356

  Fly   317 FIEINEVGTEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAI-KDNTHGLLFAGHFI 374
            .::::|.|||.||.|.|    :::|..  .|.|...::|:...| .:....:||.|..:
Human   357 ELKMDERGTEGAAGTGA----QTLPME--TPLVVKIDKPYLLLIYSEKIPSVLFLGKIV 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	102/370 (28%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	105/384 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010