DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Db and SERPINA3

DIOPT Version :9

Sequence 1:	NP_610244.2	Gene:	Spn42Db / 35599	FlyBaseID:	FBgn0033112	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001076.2	Gene:	SERPINA3 / 12	HGNCID:	16	Length:	423	Species:	Homo sapiens

Alignment Length:	371	Identity:	104/371 - (28%)
Similarity:	185/371 - (49%)	Gaps:	27/371 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FALCLHDHLCRASAGLNIIYSPLSIHISAAMLRMGTSEGSATAKEMDEGLRFGGLEAQ--QVAES 75
            ||..|:..|...:...|:|:|||||..:.|.|.:|..  :.|..|:.:||:|...|..  ::.:|
Human    56 FAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAH--NTTLTEILKGLKFNLTETSEAEIHQS 118

  Fly    76 FGVVLKSYEQCQ---VLKMANGLYVMKGLQVDEQFGHILEQKFRSKPMEIDFGSEQAA-SIINKW 136
            |..:|::..|..   .|.|.|.::|.:.|.:.::|....::.:.|:....||....|| .:||.:
Human   119 FQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDY 183

  Fly   137 VESQTNNLIKDIIGPRVLTKDSRLCLVNGIHFKGEWSISFNEKETREEDFFGSDRP-TRVRMMHV 200
            |::.|...|.|:|  :.|...:.:.|||.|.||.:|.:.|:.::|.:..|:.|.:. ..|.||
Human   184 VKNGTRGKITDLI--KDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMM-- 244

  Fly   201 CENFFFAVLPMF-----EATALRMNYSACNLAMIILLPDEKSNLTSLEKKLSDISLEVVSSAMNL 260
              :.....:|.|     ..|.:.:.|:. |.:.:.:|||: ..:..:|..|...:|:....::..
Human   245 --SLHHLTIPYFRDEELSCTVVELKYTG-NASALFILPDQ-DKMEEVEAMLLPETLKRWRDSLEF 305

  Fly   261 EKV-DVKIPSFTAEFQQELSQVLMLMGMNRIFSGQAELGGMLQSEESLFVSQIVHKAFIEINEVG 324
            .:: ::.:|.|:......|:.:|:.:|:...|:.:|:|.| :....:|.|||:||||.:::.|.|
Human   306 REIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSG-ITGARNLAVSQVVHKAVLDVFEEG 369

  Fly   325 TEAAAATAAVATFRSMPARQGPPKVFHANRPFFYAI-KDNTHGLLF 369
            |||:||||...|..|  |......:...||||...| ..:|..:.|
Human   370 TEASAATAVKITLLS--ALVETRTIVRFNRPFLMIIVPTDTQNIFF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Db	NP_610244.2	SERPIN	12..373	CDD:238101	104/371 (28%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	104/371 (28%)
		RCL	369..394		11/26 (42%)
		O-glycosylated at one site	381..389		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010