DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment coro and coro2b

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_012814523.1	Gene:	coro2b / 549719	XenbaseID:	XB-GENE-1014762	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	212/507 - (41%)
Similarity:	316/507 - (62%)	Gaps:	48/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFR-VVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPH 64
            ||:| ..|.||||:|||:...||.|||.|.::|:..|:.|||||||||||:.|:||||:|:|:|.
Frog    20 MSWRPQYRCSKFRNVYGKVASRENCYDCIPITKNVHDNHFCAVNPKFLAIVTETAGGGSFLVIPL 84

  Fly    65 NKVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVF 129
            .:.|||..::|.|.||:|.||||.|.|..:|:|||.|||..|::|:||||||.|.::|.|::|..
Frog    85 QQTGRIEPNYPKVCGHQGTVLDIKWNPFIENIIASCSEDTSVRIWEIPDGGLKRNMSEAVLELYG 149

  Fly   130 HQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCK 194
            |.|||||:.|||:|:|:|.:||.|.:::|||:..||.:..||.|.|::....||.|||.|.||||
Frog   150 HSRRVGLIEWHPTAINILFSAGYDYKILIWNLDIGEAVKMIDCHRDVILCMSFNTDGSLLATTCK 214

  Fly   195 DKKIRIYDPRTAELESEAMCHEGSKATRAIFLRH-GLIFTTGFNRSSERQYSLRAPDALNEPIVM 258
            |||:|:.:||:..:..|..| :..|.||.:||.. ..:||||.::.:.||.:|...:.|:.|:..
Frog   215 DKKLRVLEPRSGRVLQETAC-KTHKVTRVVFLGDMKRLFTTGVSKWNTRQMALWDQEDLSMPVTE 278

  Fly   259 VELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRG 323
            .|:|..:|::||.|||||:|:||.||||..|||:|:|.|.|::.|:..|::..||:|:|:|||.|
Frog   279 EEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEITAEKPYLTYLMEFRSPAPQKGLGVMPKHG 343

  Fly   324 CDVTTCEVAKFYRM-NNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            .||:.||:.:||:: ......:.|||.|||:|:.:|||:||.|...:.|:..|||:.|.:..|:.
Frog   344 LDVSACEIFRFYKLITLKNQIEPISMIVPRRSENYQEDIYPMTSGTEPALRPEEWLRGVNKGPVL 408

  Fly   388 FSLKDRVSIVQGGYVSSSVNKSL---PAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEA 449
            .|||:       ||  ...||::   |.|:..:::                        .|..:.
Frog   409 MSLKE-------GY--RKENKAIFIAPVKEKKSLV------------------------VNGIDL 440

  Fly   450 SEGGPPAAVLSEKDLRTI----QDEIRKLKAIIVKQENRIRALEAK-EDARN 496
            .|..||.   :|.:|..:    |:|||:||..:.:::..:|.||.: ::.||
Frog   441 LENVPPR---TENELLRMFFRQQEEIRRLKEQLSQRDLLVRQLELELKNLRN 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	34/56 (61%)
		WD40 repeat	37..78	CDD:293791	23/40 (58%)
		WD40	79..294	CDD:295369	104/215 (48%)
		WD40 repeat	85..129	CDD:293791	24/43 (56%)
		WD40 repeat	134..171	CDD:293791	17/36 (47%)
		WD40 repeat	178..213	CDD:293791	17/34 (50%)
		WD40 repeat	220..260	CDD:293791	13/40 (33%)
		WD40 repeat	267..308	CDD:293791	22/40 (55%)
		WD40_4	343..385	CDD:292916	18/41 (44%)
coro2b	XP_012814523.1	DUF1899	27..84	CDD:286094	34/56 (61%)
		PTZ00421	29..488	CDD:173611	206/495 (42%)
		WD40 repeat	59..99	CDD:293791	24/39 (62%)
		WD40	99..>323	CDD:295369	108/224 (48%)
		WD40 repeat	105..149	CDD:293791	24/43 (56%)
		WD40 repeat	154..191	CDD:293791	17/36 (47%)
		WD40 repeat	198..233	CDD:293791	17/34 (50%)
		WD40 repeat	239..280	CDD:293791	13/40 (33%)
		WD40 repeat	287..326	CDD:293791	22/38 (58%)
		WD40_4	364..406	CDD:292916	18/41 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R238
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960