DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment coro and coro1c

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_989383.1	Gene:	coro1c / 395017	XenbaseID:	XB-GENE-981115	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	273/498 - (54%)
Similarity:	343/498 - (68%)	Gaps:	28/498 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVG 68
            ||||.||||||:|||||.:||||:||||:.:|||:||||||.|:|||:|::|||||:|||..|.|
Frog     3 RVVRQSKFRHVFGQALKNDQCYDDIRVSRVTWDSSFCAVNPNFVAIIIEASGGGAFLVLPLQKSG 67

  Fly    69 RIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRR 133
            ||...:|.|.||.||||||.||||||||||||||||.|.|||||:.||:..||:|||.|..|.:|
Frog    68 RIDKSYPTVCGHTGPVLDIDWCPHNDNVIASGSEDCTVMVWQIPENGLTIPLTDPVVVLEGHSKR 132

  Fly   134 VGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHI-DSHPDIVYSACFNWDGSKLVTTCKDKK 197
            ||:|.|||:|.||||:||.||.:.||||||||.:.:: |.|.|::||||:|.:||.:.|..||||
Frog   133 VGIVTWHPTARNVLLSAGCDNAIFIWNVGTGEAMFNLEDMHNDMIYSACWNRNGSLICTASKDKK 197

  Fly   198 IRIYDPRTAELESEA-MCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIVMVEL 261
            :|:.|||..|:.||. ..|||::..|||||..|.||||||:|.||||.:|..|..:.|||.:.|:
Frog   198 LRVIDPRKMEVVSEKDKAHEGARPMRAIFLADGNIFTTGFSRMSERQLALWNPKNMEEPIALHEM 262

  Fly   262 DTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGCDV 326
            ||||||:.|.||.||::|||||||||.|||||:|.|.|:|||:|||.:.|||||:|.|||||.||
Frog   263 DTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDV 327

  Fly   327 TTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLK 391
            ..||:|:||:::.. .|:.|.|||||||||||:||||||...:|.|.||:|.|||:|||:..|||
Frog   328 NKCEIARFYKLHER-KCEPIIMTVPRKSDLFQDDLYPDTAGPEAPIEAEDWFDGKNADPVLISLK 391

  Fly   392 DRVSIVQGGYVSSSVNKSLPAKKAGNIL-NKPRGDSASSGATSSSAGGGNFASGNNNEASEGGPP 455
            .       |||.:........||  ||| :||.....:..|::.            .:.:|...|
Frog   392 Q-------GYVPTKGRDLNVVKK--NILGSKPAAHKKAEPASTP------------KKMTETPHP 435

  Fly   456 AAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAKEDARNKN 498
            |   |:..:..:..|:|.:|..|..|..||..||....:.|.|
Frog   436 A---SDGKMDDVMKELRSMKETIRYQGERIAKLEQLVASLNTN 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	41/56 (73%)
		WD40 repeat	37..78	CDD:293791	25/40 (63%)
		WD40	79..294	CDD:295369	135/216 (63%)
		WD40 repeat	85..129	CDD:293791	33/43 (77%)
		WD40 repeat	134..171	CDD:293791	23/37 (62%)
		WD40 repeat	178..213	CDD:293791	19/35 (54%)
		WD40 repeat	220..260	CDD:293791	22/39 (56%)
		WD40 repeat	267..308	CDD:293791	28/40 (70%)
		WD40_4	343..385	CDD:292916	28/41 (68%)
coro1c	NP_989383.1	WD40	8..467	CDD:392136	266/483 (55%)
		WD40 repeat	36..78	CDD:293791	26/41 (63%)
		WD40 repeat	84..128	CDD:293791	33/43 (77%)
		WD40 repeat	133..170	CDD:293791	23/36 (64%)
		WD40 repeat	178..213	CDD:293791	19/34 (56%)
		WD40 repeat	221..260	CDD:293791	22/38 (58%)
		WD40 repeat	268..309	CDD:293791	28/40 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56537
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1180
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		otm48752
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080