DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment coro and coro6

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_017208249.1	Gene:	coro6 / 393367	ZFINID:	ZDB-GENE-040426-1202	Length:	469	Species:	Danio rerio

Alignment Length:	492	Identity:	268/492 - (54%)
Similarity:	347/492 - (70%)	Gaps:	33/492 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||..:||.||||||:|||:|.:|.||:|||||.:|||:||||||||||:||||:|||||:|:|.:
Zfish     1 MSRSIVRQSKFRHVFGQAVKADQAYDDIRVSKVTWDSSFCAVNPKFLAVIVESSGGGAFLVMPLS 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130
            |:||:..::|||.||.||||||.|||||||::||.|||....||||||...||.::||:|.|..|
Zfish    66 KMGRVDKNYPLVVGHSGPVLDIDWCPHNDNILASCSEDTTAMVWQIPDHTPSRPISEPIVVLEGH 130

  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKD 195
            .:|||::.|||:|.|:||||||||.::||||||||.|:.:|.|||::||..:|::||...|||||
Zfish   131 SKRVGIIKWHPTARNILLTAGSDNLIIIWNVGTGEALITMDDHPDLIYSVGWNYNGSLFCTTCKD 195

  Fly   196 KKIRIYDPRTAELESEAMC-HEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIVMV 259
            :::|:.|||..|:.:|.:. |||.:..||||.|.|.||||||.|.|:|:..|..|....|||.::
Zfish   196 RRLRVCDPRKNEVVAERLSPHEGIRPMRAIFTREGNIFTTGFTRMSQRELGLWDPTNFEEPIALL 260

  Fly   260 ELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGC 324
            ||||||||:.|.||.|||::||.|||||.|||||:|.|||:||||:||.:.|||||:|.|||||.
Zfish   261 ELDTSNGVLLPFYDPDTNIVYLSGKGDSSIRYFEITEEPPYVHYISTFSSKEPQRGMGFMPKRGV 325

  Fly   325 DVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFS 389
            ||:.||:|:.|:::.. .|:.|.|||||||||||:||:|||...|.|:..|||:||:|||||..|
Zfish   326 DVSKCEIARLYKLHER-KCEPIMMTVPRKSDLFQDDLFPDTAGPDPAVEPEEWMDGRDADPILVS 389

  Fly   390 LKDRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGGP 454
            ::|       |||.....:...:||  |:|     ||..:...|.||..|:..           |
Zfish   390 MRD-------GYVPPKSRELKVSKK--NVL-----DSRPATRRSMSAVDGSSL-----------P 429

  Fly   455 PAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAK 491
            |.  |.||    :.:||:.|||.::.||.||..||.|
Zfish   430 PQ--LLEK----LIEEIQNLKATVLSQEKRICDLENK 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	42/56 (75%)
		WD40 repeat	37..78	CDD:293791	27/40 (68%)
		WD40	79..294	CDD:295369	126/215 (59%)
		WD40 repeat	85..129	CDD:293791	27/43 (63%)
		WD40 repeat	134..171	CDD:293791	24/36 (67%)
		WD40 repeat	178..213	CDD:293791	16/34 (47%)
		WD40 repeat	220..260	CDD:293791	20/39 (51%)
		WD40 repeat	267..308	CDD:293791	28/40 (70%)
		WD40_4	343..385	CDD:292916	27/41 (66%)
coro6	XP_017208249.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590027
Domainoid	1	1.000	180	1.000	Domainoid score	I3449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1154
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		otm25563
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910