Protein Alignment coro and Coro2a

DIOPT Version :9

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001012101.2
• Gene: Coro2a / 313235
• RGDID: 1309719
• Length: 543
• Species: Rattus norvegicus
• Alignment Length: 511
• Identity: 203/511 - (39%)
• Similarity: 317/511 - (62%)
• Gaps: 35/511 - (6%)

  Fly     7 RSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGRIA 71
            ||||||||||:...:|.|||::.:::|..|:.||||||.|:|::.|.||||||:|:|.::.|::.
  Rat    27 RSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLD 91

  Fly    72 ADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGL 136
            ..:|.|.||:|.||||.|.|.:|..|||.|||..:|:|.||...|:|.||....:|:.|.|||||
  Rat    92 PHYPKVCGHRGNVLDIKWNPFDDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELMGHARRVGL 156

  Fly   137 VLWHPSALNVLLTAGSDNQVVIWNVGTGEILVH-----IDSHPDIVYSACFNWDGSKLVTTCKDK 196
            |.|||:..|:|.:||.|.:|::||:.|.:.::.     |:.|.|::.|..||.:||.|.|||||:
  Rat   157 VEWHPTTANILFSAGYDYKVMVWNLDTKDSVISGPVRTINCHQDVILSMSFNTNGSLLATTCKDR 221

  Fly   197 KIRIYDPRTAELESEAMCHEGSKATRAIFLRH-GLIFTTGFNRSSERQYSLRAPDALNEPIVMVE 260
            ||||.|||...:..|| .::|.:|.:.:||.: ..:.:||.:|.:.||.:|...|.|:.|:...:
  Rat   222 KIRIVDPRLGIVLQEA-SYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDNLSVPLTEED 285

  Fly   261 LDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGCD 325
            ||.|:||:||.:|:||:|:|:.||||..|||:||:.|.|.:.|:..:::..||:|||:|||||.|
  Rat   286 LDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSTEKPHLTYLTEYRSYNPQKGIGIMPKRGLD 350

  Fly   326 VTTCEVAKFYRM-NNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFS 389
            |::||:.:||:: ....|.:.:||.|||:|:.:|||:||.|.|...::||.||:.|.:..||..|
  Rat   351 VSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMS 415

  Fly   390 LK------DRVSIVQGGYVSSSVNKSLPAKKAGNILNKPR--GDSA---------SSGATSSSAG 437
            |:      |..::.....:|:||.:..|  :....:.:|.  ||.|         :...|.....
  Rat   416 LRPGSELLDPQALPPERLLSNSVVQVSP--QPLEPVKQPAEDGDQAPFSLLEEKVTKWTTEHQLE 478

  Fly   438 GGNFASGNNNEASEGGPPAAVLSEKDLRTI----QDEIRKLKAIIVKQENRIRALE 489
            ..::.: |..:..|..||.   :|.:|..:    |:|||:|:.:::::|.:.:.||
  Rat   479 EKSWLT-NGFDIFECPPPK---TENELLQMFYRQQEEIRRLRELLIQREVQTKQLE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	32/56 (57%)
		WD40 repeat	37..78	CDD:293791	19/40 (48%)
		WD40	79..294	CDD:295369	99/220 (45%)
		WD40 repeat	85..129	CDD:293791	21/43 (49%)
		WD40 repeat	134..171	CDD:293791	16/41 (39%)
		WD40 repeat	178..213	CDD:293791	19/34 (56%)
		WD40 repeat	220..260	CDD:293791	12/40 (30%)
		WD40 repeat	267..308	CDD:293791	20/40 (50%)
		WD40_4	343..385	CDD:292916	18/41 (44%)
Coro2a	NP_001012101.2	DUF1899	27..84	CDD:286094	32/56 (57%)
		PTZ00421	29..536	CDD:173611	201/509 (39%)
		WD40 repeat	59..99	CDD:293791	20/39 (51%)
		WD40	98..327	CDD:295369	103/229 (45%)
		WD40 repeat	105..149	CDD:293791	21/43 (49%)
		WD40 repeat	154..196	CDD:293791	16/41 (39%)
		WD40 repeat	203..238	CDD:293791	20/35 (57%)
		WD40 repeat	244..285	CDD:293791	12/40 (30%)
		WD40 repeat	292..331	CDD:293791	20/38 (53%)
		WD40_4	369..411	CDD:292916	18/41 (44%)
		DUF4200	496..>534	CDD:290574	10/38 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348864
Domainoid	1	1.000	66	1.000	Domainoid score	I9685
eggNOG	1	0.900	-	-		E1_COG1985
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.660