DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment coro and Coro2b

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_038938366.1	Gene:	Coro2b / 300768	RGDID:	1561953	Length:	480	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	218/509 - (42%)
Similarity:	321/509 - (63%)	Gaps:	46/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFR-VVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPH 64
            ||:| ..||||||:|||:...||.|:|.|.::|:..|:.|||||.:||||:.||||||:|:|:|.
  Rat     6 MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNARFLAIVTESAGGGSFLVIPL 70

  Fly    65 NKVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVF 129
            .:.|||..::|.|.||:|.||||.|.|..||:|||.|||..|::|:||:|||.|.:||.:::|..
  Rat    71 EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHG 135

  Fly   130 HQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCK 194
            |.||||||.|||:..|:|.:||.|.:|:|||:..||.:..||.|.|::....||.|||.|.||||
  Rat   136 HSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDIGEPVKMIDCHTDVILCMSFNTDGSLLTTTCK 200

  Fly   195 DKKIRIYDPRTAELESEAMCHEGSKATRAIFLRH-GLIFTTGFNRSSERQYSLRAPDALNEPIVM 258
            |||:|:.:||:..:..||.| :..:..|.:||.: ..:.|||.:|.:.||.:|...:.|:.|::.
  Rat   201 DKKLRVIEPRSGRVLQEANC-KNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSMPMIE 264

  Fly   259 VELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRG 323
            .|:|..:|::||.|||||:|:||.||||..|||:|::.|.|::.|:..|::..||:|:|:|||.|
  Rat   265 EEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYLMEFRSPAPQKGLGVMPKHG 329

  Fly   324 CDVTTCEVAKFYRM-NNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            .||:.|||.:||:: ...||.:.|||.|||:||.:|||:||.|...:.|:|.:||:.|.:.||:.
  Rat   330 LDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIYPMTPGTEPALTPDEWLGGVNRDPVL 394

  Fly   388 FSLKDRVSIVQGGY-VSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASE 451
            .|||:       || .||.|....|.::..:::                        .|..:..|
  Rat   395 MSLKE-------GYKKSSKVVFKAPIREKKSVV------------------------VNGIDLLE 428

  Fly   452 GGPPAAVLSEKDLRTI----QDEIRKLKAIIVKQENRIRALEAK-EDARN--KN 498
            ..||.   :|.:|..:    |||||:||..:.:::.|:|.|:.: ::.||  ||
  Rat   429 NVPPR---TENELLRMFFRQQDEIRRLKEELAQKDIRLRQLQLELKNLRNNPKN 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	33/56 (59%)
		WD40 repeat	37..78	CDD:293791	22/40 (55%)
		WD40	79..294	CDD:295369	104/215 (48%)
		WD40 repeat	85..129	CDD:293791	24/43 (56%)
		WD40 repeat	134..171	CDD:293791	18/36 (50%)
		WD40 repeat	178..213	CDD:293791	17/34 (50%)
		WD40 repeat	220..260	CDD:293791	12/40 (30%)
		WD40 repeat	267..308	CDD:293791	21/40 (53%)
		WD40_4	343..385	CDD:292916	19/41 (46%)
Coro2b	XP_038938366.1	WD40	15..460	CDD:421866	206/479 (43%)
		WD40 repeat	45..85	CDD:293791	23/39 (59%)
		WD40 repeat	91..135	CDD:293791	24/43 (56%)
		WD40 repeat	140..177	CDD:293791	18/36 (50%)
		WD40 repeat	184..219	CDD:293791	17/34 (50%)
		WD40 repeat	225..262	CDD:293791	11/36 (31%)
		WD40 repeat	270..312	CDD:293791	22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348861
Domainoid	1	1.000	66	1.000	Domainoid score	I9685
eggNOG	1	0.900	-	-		E1_COG1985
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.660