Protein Alignment coro and crn1

DIOPT Version :9

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_593175.1
• Gene: crn1 / 2541961
• PomBaseID: SPAC23C4.02
• Length: 601
• Species: Schizosaccharomyces pombe
• Alignment Length: 560
• Identity: 197/560 - (35%)
• Similarity: 300/560 - (53%)
• Gaps: 74/560 - (13%)

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||.|.||:||:||::||..|:|.|||||::|.::|||...:|||.:|::...:..|||..|:|.|
pombe     1 MSGRFVRASKYRHIFGQTCKKELCYDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLN 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTE------PV 124
            :.|::.....|..||...|||..|.|.:|.|:|||.:|..:.:|::|:   ..|:.|      |:
pombe    66 ERGKLPDQVNLFRGHTAAVLDTDWNPFHDQVLASGGDDSKIMIWKVPE---DYTVMEPYEDVHPI 127

  Fly   125 VDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIV-YSACFNWDGSK 188
            .:|..|.|:||||.:||:|.|||.::.:||.:.:|:...|  :.|:....|:: .|..||.||::
pombe   128 AELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKG--VAHVSLKMDVMCQSMSFNADGTR 190

  Fly   189 LVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLRHGLI---FTTGFNRSSERQYSLRAPD 250
            ||||.:|||:|::||||.:..|....|.|:|..|.::|  |.:   .||||::.|:||.:|..|.
pombe   191 LVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVWL--GSLDRFATTGFSKMSDRQIALWDPT 253

  Fly   251 ALNEPI-VMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQR 314
            .|:||| ....|||.:|::.|.:|..|.:|||.||||..|||:|.  |....||::.|::.:|||
pombe   254 NLSEPIGGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEY--ENDVFHYLSEFKSVDPQR 316

  Fly   315 GIGLMPKRGCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWID 379
            ||..:||||.:|:..||.:.|:..|:.:.:.||..|||:|:.||.|:||...:...::|||||..
pombe   317 GIAFLPKRGVNVSENEVMRAYKSVNDSIIEPISFIVPRRSESFQSDIYPPAPSGKPSLTAEEWAS 381

  Fly   380 GKDADPITFSLKDRVSIVQG-GYVSSSVNKSLPA----------------KKAGNILNKPRGDSA 427
            ||||.|   .|.|..::.:. |.|..:|:.::|:                |.....::||: :||
pombe   382 GKDAQP---DLLDMSTLYESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPK-ESA 442

  Fly   428 SSGATSSSAGGGNFASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAK- 491
            .....|...           |.....|.|:.:.|...:  :||....|...|.|..|.:....|
pombe   443 EEQKPSKEP-----------EVKPTTPSASKVEEPSKK--RDEDNHQKEETVTQPKREKTPVEKS 494

  Fly   492 ------------EDARNKNG-------SDAAPASAGAATS 512
                        ||.:.:..       ||.||.:|..|.|
pombe   495 FPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAES 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	26/56 (46%)
		WD40 repeat	37..78	CDD:293791	13/40 (33%)
		WD40	79..294	CDD:295369	91/225 (40%)
		WD40 repeat	85..129	CDD:293791	16/49 (33%)
		WD40 repeat	134..171	CDD:293791	15/36 (42%)
		WD40 repeat	178..213	CDD:293791	18/34 (53%)
		WD40 repeat	220..260	CDD:293791	16/43 (37%)
		WD40 repeat	267..308	CDD:293791	17/40 (43%)
		WD40_4	343..385	CDD:292916	20/41 (49%)
crn1	NP_593175.1	DUF1899	7..64	CDD:286094	26/56 (46%)
		WD40	77..>324	CDD:295369	102/255 (40%)
		WD40 repeat	85..132	CDD:293791	16/49 (33%)
		WD40 repeat	137..172	CDD:293791	15/36 (42%)
		WD40 repeat	180..215	CDD:293791	18/34 (53%)
		WD40 repeat	222..263	CDD:293791	16/42 (38%)
		WD40 repeat	271..308	CDD:293791	17/38 (45%)
		WD40_4	345..387	CDD:292916	20/41 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG1985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56537
Inparanoid	1	1.050	319	1.000	Inparanoid score	I553
OMA	1	1.010	-	-		QHG53996
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		oto101446
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R238
SonicParanoid	1	1.000	-	-		X216
TreeFam	0	0.000	Not matched by this tool.
	13	12.900