DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment coro and CORO1A

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_016878374.1	Gene:	CORO1A / 11151	HGNCID:	2252	Length:	463	Species:	Homo sapiens

Alignment Length:	448	Identity:	240/448 - (53%)
Similarity:	315/448 - (70%)	Gaps:	23/448 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||.:||||||||||:||..|.:|||:::|||:::|||.||||||||:|:|.|::|||||:|||..
Human     1 MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLG 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130
            |.||:..:.|.|.||..||||||||||||||||||||||.|.||:||||||...|.||||.|..|
Human    66 KTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGH 130

  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHI--DSHPDIVYSACFNWDGSKLVTTC 193
            .:|||:|.||.:|.||||:||.||.:::|:||||..::.:  :.|||.:||..::.||..:.|:|
Human   131 TKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSC 195

  Fly   194 KDKKIRIYDPRTAELESEA-MCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIV 257
            :||::||.:||...:.:|. ..|||::..||:|:..|.|.||||:|.||||.:|.....|.||:.
Human   196 RDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLS 260

  Fly   258 MVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKR 322
            :.|||||:||:.|.:|.|||::||||||||.|||||:|.|.||:||::.|.:.|.|||:|.||||
Human   261 LQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKR 325

  Fly   323 GCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            |.:|..||:|:||:::.. .|:.|:||||||||||||||||.|...|.|:|||||:.|:||.|:.
Human   326 GLEVNKCEIARFYKLHER-RCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLL 389

  Fly   388 FSLKDRVSIVQGGYVSSS-----VNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGN 440
            .||||       |||...     ||:.|..       .:.|....:||..||..|.|:
Human   390 ISLKD-------GYVPPKSRELRVNRGLDT-------GRRRAAPEASGTPSSVRGLGS 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	38/56 (68%)
		WD40 repeat	37..78	CDD:293791	24/40 (60%)
		WD40	79..294	CDD:295369	121/217 (56%)
		WD40 repeat	85..129	CDD:293791	35/43 (81%)
		WD40 repeat	134..171	CDD:293791	19/38 (50%)
		WD40 repeat	178..213	CDD:293791	13/35 (37%)
		WD40 repeat	220..260	CDD:293791	18/39 (46%)
		WD40 repeat	267..308	CDD:293791	25/40 (63%)
		WD40_4	343..385	CDD:292916	29/41 (71%)
CORO1A	XP_016878374.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154992
Domainoid	1	1.000	174	1.000	Domainoid score	I3679
eggNOG	1	0.900	-	-		E1_COG1985
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1222
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		otm41540
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R238
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800