DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment coro and coro6

DIOPT Version :9

Sequence 1:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001164994.1	Gene:	coro6 / 100038129	XenbaseID:	XB-GENE-493511	Length:	471	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	264/491 - (53%)
Similarity:	338/491 - (68%)	Gaps:	33/491 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||.||||.|||||::||.:|.:|.|::|||||.:|||:||||||||:||||||:|||||||||..
Frog     1 MSRRVVRQSKFRHIFGQPVKADQMYEDIRVSKVTWDSSFCAVNPKFIAIIVESSGGGAFIVLPLA 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130
            |.||:..:||.|.||..|||||.|||||||||||.|:|..|.||||||....|::|||:|.|..|
Frog    66 KTGRVDKNHPTVSGHTAPVLDIDWCPHNDNVIASASDDTTVMVWQIPDYTPVRSITEPIVTLEGH 130

  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDS-HPDIVYSACFNWDGSKLVTTCK 194
            .:|||:|.|||||.|:||:||.||.::||||||||.|:::|. |.|::||.|:|::||.:.||||
Frog   131 SKRVGIVKWHPSARNILLSAGGDNAIIIWNVGTGEALINLDELHSDLIYSICWNYNGSLITTTCK 195

  Fly   195 DKKIRIYDPRTAELESEAMC-HEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIVM 258
            |||:|:.|||..|:.:|.:. |||.:..||||.|.|.||||||.|.|:|:..|..|...:|||.:
Frog   196 DKKVRVIDPRKQEIVAERLAPHEGMRPMRAIFTRDGNIFTTGFTRMSQRELGLWDPSNFDEPIAL 260

  Fly   259 VELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRG 323
            .|:||||||:.|.||:|:|::||||||||.|||||:|.|.|||||::|:.:.|||||:|.|||||
Frog   261 QEMDTSNGVLLPFYDSDSNVVYLCGKGDSSIRYFEITAEAPFVHYLSTYSSKEPQRGMGFMPKRG 325

  Fly   324 CDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITF 388
            .||:.||:|:|::::.. .|:.|.|||||||||||:||||||...:.|:.||||..|:|||||..
Frog   326 LDVSKCEIARFFKLHER-KCEPIVMTVPRKSDLFQDDLYPDTPGPEPALEAEEWFSGQDADPILV 389

  Fly   389 SLKDRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGG 453
            ||:|       ||.... |:.|...|...:.|||......| .:|..||
Frog   390 SLRD-------GYTPLK-NRELKVNKKNILDNKPPTGPRRS-YSSCDAG---------------- 429

  Fly   454 PPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALE 489
                 .|...|..:.:||:.|:|.:..||.||..||
Frog   430 -----FSRVSLEDLVEEIKSLRATVESQEKRISDLE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	41/56 (73%)
		WD40 repeat	37..78	CDD:293791	29/40 (73%)
		WD40	79..294	CDD:295369	128/216 (59%)
		WD40 repeat	85..129	CDD:293791	29/43 (67%)
		WD40 repeat	134..171	CDD:293791	24/36 (67%)
		WD40 repeat	178..213	CDD:293791	19/34 (56%)
		WD40 repeat	220..260	CDD:293791	20/39 (51%)
		WD40 repeat	267..308	CDD:293791	27/40 (68%)
		WD40_4	343..385	CDD:292916	27/41 (66%)
coro6	NP_001164994.1	WD40	9..428	CDD:392136	244/428 (57%)
		WD40 repeat	37..79	CDD:293791	30/41 (73%)
		WD40 repeat	85..129	CDD:293791	29/43 (67%)
		WD40 repeat	134..171	CDD:293791	24/36 (67%)
		WD40 repeat	179..215	CDD:293791	19/35 (54%)
		WD40 repeat	222..262	CDD:293791	20/39 (51%)
		WD40 repeat	269..310	CDD:293791	27/40 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1180
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		otm48752
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060