Protein Alignment coro and coro1a

DIOPT Version :9

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_957408.1
• Gene: coro1a / 100002113
• ZFINID: ZDB-GENE-030131-9512
• Length: 455
• Species: Danio rerio
• Alignment Length: 494
• Identity: 250/494 - (50%)
• Similarity: 342/494 - (69%)
• Gaps: 42/494 - (8%)

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||.:||||||||||:|||:|.:||||:||:|:.:|||.||:|||||:::||:::|||||||||.:
Zfish     1 MSRKVVRSSKFRHVFGQAVKADQCYDDIRISQMTWDSNFCSVNPKFVSMIVDASGGGAFIVLPLS 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130
            |.|||....|.|.||.||||||.:||||||:||||||||.|.:|:||:|||...|.:|||.|..|
Zfish    66 KTGRIDMSQPTVCGHTGPVLDIEFCPHNDNIIASGSEDCSVMIWEIPEGGLVTPLRDPVVKLEGH 130

  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDS-HPDIVYSACFNWDGSKLVTTCK 194
            .:|||||.|||:|.|||::||.||.|::|||..||.:|.||: |.|::||.|:|.:||:::|.||
Zfish   131 SKRVGLVSWHPTAHNVLMSAGCDNVVILWNVARGEAVVRIDTVHTDLIYSVCWNRNGSQILTACK 195

  Fly   195 DKKIRIYDPR--TAELESEAMCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIV 257
            |||:|:.|||  |...|.:.. ||||:..||:|:..|.|.||||:|.||||.:|..|:...||:.
Zfish   196 DKKLRVIDPRKGTVIYEKDKP-HEGSRPVRAVFVSDGKILTTGFSRMSERQVALWDPNNFGEPLT 259

  Fly   258 MVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKR 322
            :.|||||:||:.|.:|.||.::||||||||.|||||||.|.|:|||::.:.:.|.|:|:|.||||
Zfish   260 LQELDTSSGVLLPFFDPDTGIVYLCGKGDSSIRYFEVTDEAPYVHYLSMYSSKESQKGMGYMPKR 324

  Fly   323 GCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            |.:|..||:|:||:::.. .|:.:.||||||||||||||||:|:..:.::.|::|..|||.:||.
Zfish   325 GLEVNKCEIARFYKLHER-KCEPVVMTVPRKSDLFQEDLYPNTVGPEPSVEADDWFAGKDGEPIL 388

  Fly   388 FSLKDRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEG 452
            .||||       |:|:::.||.....|           |..|..:|||.          |..|:.
Zfish   389 ISLKD-------GFVATTKNKEFKVIK-----------SLMSTTSSSSC----------NRQSDS 425

  Fly   453 GPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAK 491
            |         |::.:|:|::|||.::.....|:..||:|
Zfish   426 G---------DVQALQNEVKKLKEMVEDLTKRVNDLESK 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	39/56 (70%)
		WD40 repeat	37..78	CDD:293791	24/40 (60%)
		WD40	79..294	CDD:295369	125/217 (58%)
		WD40 repeat	85..129	CDD:293791	29/43 (67%)
		WD40 repeat	134..171	CDD:293791	22/36 (61%)
		WD40 repeat	178..213	CDD:293791	18/36 (50%)
		WD40 repeat	220..260	CDD:293791	18/39 (46%)
		WD40 repeat	267..308	CDD:293791	25/40 (63%)
		WD40_4	343..385	CDD:292916	23/41 (56%)
coro1a	NP_957408.1	DUF1899	7..64	CDD:286094	39/56 (70%)
		WD40 repeat	39..79	CDD:293791	24/39 (62%)
		WD40	76..301	CDD:295369	130/225 (58%)
		WD40 repeat	85..129	CDD:293791	29/43 (67%)
		WD40 repeat	134..171	CDD:293791	22/36 (61%)
		WD40 repeat	179..214	CDD:293791	18/34 (53%)
		WD40 repeat	223..262	CDD:293791	18/38 (47%)
		WD40 repeat	269..310	CDD:293791	25/40 (63%)
		WD40_4	344..386	CDD:292916	23/41 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590024
Domainoid	1	1.000	180	1.000	Domainoid score	I3449
eggNOG	1	0.900	-	-		E1_COG1985
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1154
OMA	1	1.010	-	-		QHG53996
OrthoDB	1	1.010	-	-		D552726at2759
OrthoFinder	1	1.000	-	-		FOG0000390
OrthoInspector	1	1.000	-	-		otm25563
orthoMCL	1	0.900	-	-		OOG6_100479
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R238
SonicParanoid	1	1.000	-	-		X216
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800