DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment koi and Sun1

DIOPT Version :9

Sequence 1:	NP_001260738.1	Gene:	koi / 35594	FlyBaseID:	FBgn0265003	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_017176645.1	Gene:	Sun1 / 77053	MGIID:	1924303	Length:	951	Species:	Mus musculus

Alignment Length:	1099	Identity:	274/1099 - (24%)
Similarity:	404/1099 - (36%)	Gaps:	411/1099 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ETR----RRSRSKTPF---------LRSSCDHENCEHAGEEGHVHHLKRKSAAPNVQTIIEEHIV 60
            |||    |||.||..|         |.||..|::                |.:....|::...::
Mouse   117 ETRTVKQRRSASKPAFSINHLSGKGLSSSTSHDS----------------SCSLRSATVLRHPVL 165

  Fly    61 -ESSISKKTRAKAFAQLTSDYSSDDMTPDAKRKQNSITATVTSILTKRSGGATSTPRNRSQLE-- 122
             ||.|.::|:...|..|..|              ..:.|.:|.:  |.|||..:..:...:|.
Mouse   166 DESLIREQTKVDHFWGLDDD--------------GDLKAFITPL--KTSGGNKAATQGNGELAAE 214

  Fly   123 ----------------------TTQNTLNSAQEKLNQSNGNLSSGNVSDYLAYIEYRDAGEYWNK 165
                                  |..:.::....::...:..|....||.||      |...:..|
Mouse   215 VASSNGYTCRDCRMLSARTDALTAHSAIHGTTSRVYSRDRTLKPRGVSFYL------DRTLWLAK 273

  Fly   166 TPKTDYTYSELSPHRRQLAPGIVAMPNMSRKSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQ 230
            :     |.|..:....||...::...|.....|:.:..|.                 |:|:..:.
Mouse   274 S-----TSSSFASFIVQLFQVVLMKLNFETYKLKGYESRA-----------------YESQSYET 316

  Fly   231 VNYDS-----------ADELD---------------------ATFGQQKQ----SWWLIRLI--- 256
            .:::|           |.||.                     ||..|..|    :..:.||.
Mouse   317 KSHESEAHLGHCGRMTAGELSRVDGESLCDDCKGKKHLEIHTATHSQLPQPHRVAGAMGRLCIYT 381

  Fly   257 -QLVVSSI-----------TTVWSRV-TNLSATETTAYQNYHAKRQQSQQVGLWWKIVQTIGGG- 307
             .|:|.::           ..|||.: ..:||....|...:            ||     :|.|
Mouse   382 GDLLVQALRRTRAAGWSVAEAVWSVLWLAVSAPGKAASGTF------------WW-----LGSGW 429

  Fly   308 --LASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPLLLLSG------------ 358
              ..:|:.:|.||      |.|..||     |..|    :|:| |||||||.|
Mouse   430 YQFVTLISWLNVF------LLTRCLR-----NICK----VFVL-LLPLLLLLGAGVSLWGQGNFF 478

  Fly   359 -------WLLLQEDQR---SAYVQRAEALLPLPLSIFGSLRSRFSNAGATLKSWMEVPTVRSPQR 413
                   |..:|..||   |..:.|...|.|.|........|:          |        ||.
Mouse   479 SLLPVLNWTAMQPTQRVDDSKGMHRPGPLPPSPPPKVDHKASQ----------W--------PQE 525

  Fly   414 EAEAIKVNMASIEQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKE 478
            .....||          .:|:|:                    ...|.:.||
Mouse   526 SDMGQKV----------ASLSAQ--------------------CHNHDERLA------------- 547

  Fly   479 NLKQIMYKTELSEKDLSDLAIKLKLELQSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYTIQ 543
                          :|:.|..||::.:......::|..|...|:        ...||.|
Mouse   548 --------------ELTVLLQKLQIRVDQVDDGREGLSLWVKNV--------VGQHLQE------ 584

  Fly   544 LDRIDFASLLERILAAPALADFVDARISLRVGELEPKESSGS-----SDAEVQIERLNREIAFIK 603
                                          :|.:||.::...     .|.||::.  |.|....|
Mouse   585 ------------------------------MGTIEPPDAKTDFMTFHHDHEVRLS--NLEDVLRK 617

  Fly   604 LALSDKQAENADLHQSISNLKLGQED----LLERIQQHELSQDRRFHGLLAEIENKLSALNDSQF 664
            |. ...:|...:|.:  :.||.|..|    ||:|:|..||           |:....|.|:|.|.
Mouse   618 LT-EKSEAIQKELEE--TKLKAGSRDEEQPLLDRVQHLEL-----------ELNLLKSQLSDWQH 668

  Fly   665 ---------ALLNKQIKLSLVEILGFKQSTAGGSAGQLDDFDLQTW----VRSMFVAKDYLEQQL 716
                     |.:.:.::|.      |.:...|||.         .|    :.|.||:||.|:..|
Mouse   669 LKTSCEQAGARIQETVQLM------FSEDQQGGSL---------EWLLEKLSSRFVSKDELQVLL 718

  Fly   717 LELNKRTNNNIRDEI-----ERSSILLMSDISQRLKREILLVVEAKHNESTKALKGHIREEEVRQ 776
            .:|..:...||...|     ..:|..::|.::|                  ..:.| |.|.:...
Mouse   719 HDLELKLLQNITHHITVTGQAPTSEAIVSAVNQ------------------AGISG-ITEAQAHI 764

  Fly   777 IVKTVLAIYDADKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPN 841
            ||...|.:|..||||:|||||||.||.||||||:|:|:||:|.:|:||:||||.:.:|||.|.|:
Mouse   765 IVNNALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPLWYFSQSPRVVIQPD 829

  Fly   842 VQPGECWAFQGFPGFLVLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPV 906
            :.||.||||:|..|:||::|:..:|.|.||:|||||:|||||.|.|||::|.|:|||.|..:|..
Mouse   830 IYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLSPTGNISSAPKDFAVYGLETEYQEEGQ 894

  Fly   907 LFGDYQFEDNGASLQYFAVQNLDIKRP---YEIVELRIETNHGHPTYTCLYRFRVHGKP 962
            ..|.:.::..|.|||.|..    ::||   ::|||||:.:|.|||.|||||||||||:|
Mouse   895 PLGRFTYDQEGDSLQMFHT----LERPDQAFQIVELRVLSNWGHPEYTCLYRFRVHGEP 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
koi	NP_001260738.1	Sad1_UNC	827..962	CDD:285038	72/137 (53%)
Sun1	XP_017176645.1	MRP	102..259	CDD:370461	31/173 (18%)
		CALCOCO1	543..>706	CDD:369575	46/264 (17%)
		Sun2_CC2	<747..772	CDD:376006	8/43 (19%)
		Sad1_UNC	815..949	CDD:369494	72/137 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4314
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000864
OrthoInspector	1	1.000	-	-		otm43418
orthoMCL	1	0.900	-	-		OOG6_102039
Panther	1	1.100	-	-	O	PTHR12911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2888
SonicParanoid	1	1.000	-	-		X471
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.940