Protein Alignment koi and SUN1

DIOPT Version :10

• Sequence 1: NP_001260738.1
• Gene: koi / 35594
• FlyBaseID: FBgn0265003
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: NP_001354580.1
• Gene: SUN1 / 23353
• HGNCID: 18587
• Length: 923
• Species: Homo sapiens
• Alignment Length: 1008
• Identity: 259/1008 - (25%)
• Similarity: 413/1008 - (40%)
• Gaps: 305/1008 - (30%)

  Fly    76 LTSDYSSDDM-------------TPDAKRKQNSITATVTSILTKRSGGATS------TPRNRSQL 121
            ::|.||||.:             :|...|:...:..|..::....:.||.|      :.:||:..
Human    98 VSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAAR 162

  Fly   122 ETTQ-NTLNSAQEKLNQSNGNLSSGNVSDYLAYIEYRDA--------GEYWNKTPKT-DYTY--- 173
            .|.| .:.|.:...:|..:..::|..|| :...:..:||        .|.|.:...| |:.:
Human   163 TTKQRRSTNKSAFSINHVSRQVTSSGVS-HGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLD 226

  Fly   174 -----------------------------------SELSPHRRQL-----APGIVA---MPNMSR 195
                                               |.||..:..|     |||.|:   ..:.::
Human   227 DDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQ 291

  Fly   196 KSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQVNYDSAD---ELDATFGQQKQS-------- 249
            ||..::..|:|.        .|.:|.........:...|...   .|||......||
Human   292 KSHASYYGRMNV--------REVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAG 348

  Fly   250 --W--W---------LIRLIQLVVSSIT-TVWSRVTNLSATETTAYQNYHAKRQQSQQVGLWWKI 300
              |  |         ::|.|..|..::: |.||                          .||..:
Human   349 TLWHIWACAGYFLLQILRRIGAVGQAVSRTAWS--------------------------ALWLAV 387

  Fly   301 VQTIGGGLASLLRYL----YVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPL-LLLSGWL 360
            |.. |...:.:..:|    |.|:..:..|:.:||      .:..:....||::|:|| |||:|..
Human   388 VAP-GKAASGVFWWLGIGWYQFVTLISWLNVFLL------TRCLRNICKFLVLLIPLFLLLAGLS 445

  Fly   361 LLQEDQRSAYVQRAEALLPLPLSIFGSLRSRFSNAGATLKSWMEVPTVRSPQREAEAIKVNMASI 425
            |..:....::         ||:..:.|:.              ....|..||   :..|...:.:
Human   446 LRGQGNFFSF---------LPVLNWASMH--------------RTQRVDDPQ---DVFKPTTSRL 484

  Fly   426 EQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLKQIMYKTELS 490
            :|.:|....|..:    :.::...||:..|..|.|..              .|||
Human   485 KQPLQGDSEAFPW----HWMSGVEQQVASLSGQCHHH--------------GENL---------- 521

  Fly   491 EKDLSDLAIKLKLELQSSGGWQDGAKLSQANLEEITKLIKAE---VHLHESHYTIQLDRIDFASL 552
             ::|:.|..||:..:....|   ||....|::.:.......|   :..|:.| .:::      |.
Human   522 -RELTTLLQKLQARVDQMEG---GAAGPSASVRDAVGQPPRETDFMAFHQEH-EVRM------SH 575

  Fly   553 LERILAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNREIAFIKLALSDKQAENADLH 617
            ||.||                 |:|..|.           |.:.:|:...|             .
Human   576 LEDIL-----------------GKLREKS-----------EAIQKELEQTK-------------Q 599

  Fly   618 QSISNLKLGQEDLLERIQQHELSQDRRFHGLLAEIENKLSALN---------DSQFALLNKQIKL 673
            ::||.:   .|.||..::..:|..|        :::::||:..         |:....::.|::
Human   600 KTISAV---GEQLLPTVEHLQLELD--------QLKSELSSWRHVKTGCETVDAVQERVDVQVR- 652

  Fly   674 SLVEILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLELNKRTNNNIRDEIERSSILL 738
            .:|::| |.:...|||..||    ||.: .|.||:|..|:..|.:|..:...|:...:..:..|.
Human   653 EMVKLL-FSEDQQGGSLEQL----LQRF-SSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP 711

  Fly   739 MSDISQRLKREILLVVEAKHNESTKALKGHIREEEVRQIVKTVLAIYDADKTGLVDFALESAGGQ 803
            .|              ||..:..::|....|.|.:.|.||.:.|.:|..||||:|||||||.||.
Human   712 TS--------------EAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGS 762

  Fly   804 ILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPNVQPGECWAFQGFPGFLVLKLNSLVYVT 868
            ||||||:|:|:||:|.:|:|||||||.:.:|||.|.|::.||.||||:|..|:||::|:.:::..
Human   763 ILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPA 827

  Fly   869 GFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPVLFGDYQFEDNGASLQYFAVQNLDIKRP 933
            .||||||||:|||||.|.|||::|.|:|||.|..:|..|.|.:.::.:|.|||.|..    :|||
Human   828 AFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQA----LKRP 888

  Fly   934 ----YEIVELRIETNHGHPTYTCLYRFRVHGKP 962
                ::||||||.:|.|||.|||||||||||:|
Human   889 DDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEP 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
koi	NP_001260738.1	PRK03918	<462..>653	CDD:235175	32/193 (17%)
		Sad1_UNC	827..962	CDD:400199	74/138 (54%)
SUN1	NP_001354580.1	MRP	135..429	CDD:430576	56/335 (17%)
		SUN1_cc1	555..608	CDD:410605	16/103 (16%)
		CwlO1	567..>700	CDD:443091	40/198 (20%)
		HTH_SUN2	685..743	CDD:436594	15/71 (21%)
		Sad1_UNC	786..921	CDD:400199	74/138 (54%)