Protein Alignment koi and Sun2

DIOPT Version :10

• Sequence 1: NP_001260738.1
• Gene: koi / 35594
• FlyBaseID: FBgn0265003
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: NP_001192274.1
• Gene: Sun2 / 223697
• MGIID: 2443011
• Length: 731
• Species: Mus musculus
• Alignment Length: 943
• Identity: 243/943 - (25%)
• Similarity: 387/943 - (41%)
• Gaps: 272/943 - (28%)

  Fly    74 AQLTSDYSSDDMTPDAKRKQNSITATVTSILTKRSGGATSTPRNRSQLETTQNTL--NSAQEKLN 136
            :|..:.||.||                      ..||::|:  ..|.:..:|.|:  :|....|.
Mouse     5 SQRLTRYSQDD----------------------NDGGSSSS--GASSVAGSQGTVFKDSPLRTLK 45

  Fly   137 QSNGNLSS-------GNVSD-YLAYIEYRDAGEYWNKTPKT----------DYTYSE------LS 177
            :.:.|:..       |..|| :.:|.......|.:..:|:.          |:.:||      |.
Mouse    46 RKSSNMKHLSPAPQLGPSSDSHTSYYSESVVRESYIGSPRAVSLARSALLDDHLHSEPYWSGDLR 110

  Fly   178 PHRRQLAPGIVAMPNMSRKSLENHNDRVNYMVQQNPAQEEFI--RRRYQSK-----YTQQVNYDS 235
            ..||:...|             :.:.:.|.:..::.|.|:|.  ...|.|:     ||....:.|
Mouse   111 GRRRRGTGG-------------SESSKANGLTAESKASEDFFGSSSGYSSEDDLAGYTDSDQHSS 162

  Fly   236 ADELDATFGQQKQSWWLI-----RLIQLVVSSITTVWSRVTNLSATETTAYQNYHAKRQQSQQVG 295
            ...|.:...:.....|.:     ||..|:...|.|.|.|:       |||
Mouse   163 GSRLRSAASRAGSFVWTLVTFPGRLFGLLYWWIGTTWYRL-------TTA--------------- 205

  Fly   296 LWWKIVQTIGGGLASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPL--LLLSG 358
                         |||             ||.::|..|...:.:.|.||.|||:||.|  |....
Mouse   206 -------------ASL-------------LDVFVLTRSRHFSLNLKSFLWFLLLLLLLTGLTYGA 244

  Fly   359 WLLLQEDQRSAYVQRAEALLPLPLSIFGSLRSRFSNAGATLKSWMEVPTVRSPQREAEAIKVNMA 423
            |        ..|....:.|.|..:|.:.:..||                     ::.|..:...|
Mouse   245 W--------HFYPLGLQTLQPAVVSWWAAKESR---------------------KQPEVWESRDA 280

  Fly   424 SIEQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLKQIMYKTE 488
            |  |:.|    ||  :.:|:.|:|..::|..|.....|            ...||
Mouse   281 S--QHFQ----AE--QRVLSRVHSLERRLEALAADFSS------------NWQKE---------- 315

  Fly   489 LSEKDLSDLAIKL-KLEL-QSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYTIQLD-RIDFA 550
                     ||:| :||| |.:.|...|:.||.   |:...|::..|...|:  |::.| |.|..
Mouse   316 ---------AIRLERLELRQGAAGHGGGSSLSH---EDALSLLEGLVSRREA--TLKEDLRRDTV 366

  Fly   551 SLLERILAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNRE------IAFIKLALSD- 608
            :.::..||........|:.      :|..|....|.::|.::::|..|      .||.:.::.:
Mouse   367 AHIQEELATLRAEHHQDSE------DLFKKIVQASQESEARVQQLKTEWKSMTQEAFQESSVKEL 425

  Fly   609 --KQAENADLHQSISNLKLGQEDLLERIQQHELSQDRRFHGLLAEIENKLSALNDSQFALLNKQI 671
              .:|:.|.|.|.::.|.|.|..:.:.:            |||.:......|..:|||....:|.
Mouse   426 GRLEAQLASLRQELAALTLKQNSVADEV------------GLLPQKIQAARADVESQFPDWIRQF 478

  Fly   672 KLSLVEILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLELNKRTNNNIRDEIERSSI 736
            .|              |..|          .||..:.:|.:..||.||..:....:.:...:|:.
Mouse   479 LL--------------GDRG----------ARSGLLQRDEMHAQLQELENKILTKMAEMQGKSAR 519

  Fly   737 LLMSDISQRLKREILLVVEAKHNESTKALKGHIREEEVRQIVKTVLAIYDADKTGLVDFALESAG 801
            ...:.:.|.|::|.::               .:.||:|.:|||..|..|..|:.|:||:||||.|
Mouse   520 EAAASLGQILQKEGIV---------------GVTEEQVHRIVKQALQRYSEDRIGMVDYALESGG 569

  Fly   802 GQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPNVQPGECWAFQGFPGFLVLKLNSLVY 866
            ..::||||:|:|:||:|.:|:|||||||.:.:|||.:.|:|.||.||||||..||.|::|::.:.
Mouse   570 ASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIR 634

  Fly   867 VTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPVLFGDYQFEDNGASLQ--YFAVQNLD 929
            .|..||||:||:|||...|.|||::|.::|.:::..||..|.|.:.::.:|..:|  ||....:
Mouse   635 PTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGTFAYDQDGEPIQTFYFQASKM- 698

  Fly   930 IKRPYEIVELRIETNHGHPTYTCLYRFRVHGKP 962
              ..|::|||||.||.|||.|||:|||||||:|
Mouse   699 --ATYQVVELRILTNWGHPEYTCIYRFRVHGEP 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
koi	NP_001260738.1	PRK03918	<462..>653	CDD:235175	42/202 (21%)
		Sad1_UNC	827..962	CDD:400199	65/136 (48%)
Sun2	NP_001192274.1	LMNA-binding	1..128		28/159 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		17/87 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..142		8/48 (17%)
		COG4913	<252..>472	CDD:443941	63/302 (21%)
		SUN2_cc1	414..468	CDD:410604	13/65 (20%)
		HTH_SUN2	495..552	CDD:436594	15/71 (21%)
		Sufficient for interaction with SYNE1 and SYNE2. /evidence=ECO:0000250|UniProtKB:Q9UH99	521..731		100/227 (44%)
		Sad1_UNC	595..729	CDD:400199	65/136 (48%)