DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment koi and sun1

DIOPT Version :9

Sequence 1:	NP_001260738.1	Gene:	koi / 35594	FlyBaseID:	FBgn0265003	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_002941852.3	Gene:	sun1 / 100137098	XenbaseID:	XB-GENE-995941	Length:	941	Species:	Xenopus tropicalis

Alignment Length:	955	Identity:	249/955 - (26%)
Similarity:	390/955 - (40%)	Gaps:	276/955 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NSITATVTSILTKRSGGATSTPRNRS---QLETTQNT------LNSAQEKLNQSNGNLSSGNVSD 149
            |..|.:..||:::|:...|:...:.|   ::..|..|      |::.....|.::||:.:|:.:.
Frog   175 NGYTCSDCSIVSQRNDALTALSASYSSSGKVHATSGTHTACGMLHTGSTITNAASGNVHAGSANA 239

  Fly   150 YL---------AYIEYRDAGEYWNKTPKTDY-----------TYSELSPHRRQLAPGIVAMPNMS 194
            :.         ..:..||..:. ||:.:..:           |.|.|:....:|...::......
Frog   240 HTPSSSMHTSSTRVYSRDRSQK-NKSREIPFYMHKAMLLFKNTASSLATVVVRLLHMVMLKLGCD 303

  Fly   195 RKSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQVNYDSADELDATFGQQKQSWWLIRLIQLV 259
            .|:..|:...||.   ::..:|:.:.|..........|.....|:..|...| .||
Frog   304 LKAHLNYCGSVNV---RDFLKEDGLLRINGKSLCDDYNGTKHHEMRTTIHTQ-SSW--------- 355

  Fly   260 VSSIT-TVWSRVTNLSATETTAYQNYHAKRQQSQQVG---------------------------- 295
            ...:| |:|.          |.|...:...|..:.||
Frog   356 ARGVTGTLWH----------TLYYTGYLLLQAVRSVGAAGWFVSRKMLSFLWLAIVSPGRAASSL 410

  Fly   296 LWWKIVQTIGGG---LASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPLLLLS 357
            |||     :|.|   ||:|:..|.|||         |.|.....:|       .||:|||||:|.
Frog   411 LWW-----LGTGWYQLATLVSLLNVFI---------LTRCLSKLSK-------LLLLLLPLLILL 454

  Fly   358 GWLLLQEDQRSAYVQRAEALLPLPLSIFGSLRSRFSN-----AGATLKSWMEVPTVRSPQREAEA 417
            |..|...|    |:     |||    .||.||. ||:     ...:|:...|..|:.||..:.|.
Frog   455 GLYLWGSD----YI-----LLP----AFGGLRI-FSSDVLEETAHSLEPSPESTTISSPGTKEEG 505

  Fly   418 IKVNMASI-EQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLK 481
            :..:...| |...|..|...::.   .|:..|
Frog   506 LPYDTDRIRELEKQFGLMGRKHN---GHMEDY--------------------------------- 534

  Fly   482 QIMYKTELSEKDLSDLAIKLKLELQSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYTIQLDR 546
                      |.|:.|.:|::.::|.   ..|.:.||..    ||.:.:.    |.:.:|::...
Frog   535 ----------KKLNVLVLKIQEQVQQ---MNDESHLSSI----ITNMFEQ----HFAKHTVEKKE 578

  Fly   547 IDFASLLERILAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNREIAFIKLA------ 605
                         |:    |||            .||.:|:.|.:|..|  |..|.||:
Frog   579 -------------PS----VDA------------SSSTASNHEARIVHL--EALFAKLSQAIEED 612

  Fly   606 --LSDKQAENADLHQSISNLKLGQEDLLERIQQHELSQDRRFHGLLAEIENKLSALNDSQFALLN 668
              |::.:....::|         .|.||.          ||...|..|.|...:|..:.|.|
Frog   613 RKLAESRTSRGEIH---------DESLLR----------RRIESLEEEFETYKAAFTNRQTA--- 655

  Fly   669 KQIKLSLVEILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLE------LNKRTNNNI 727
             |....|.:.|           .|..|..::..:..||.:::.:.:.||:      :||...|:.
Frog   656 -QTSCDLPDCL-----------LQKVDARVKESIHMMFASQENIPESLLQWLSANYVNKGDFNSR 708

  Fly   728 RDEIERSSILLMSDISQRLKREILL---VVEAKHNES--TKALKGHIREEEVRQIVKTVLAIYDA 787
            ..|:|..       |.|.:...::|   |..||..|:  |.|:.| |.::|.:.::...|.:|..
Frog   709 LQELELK-------ILQNITHHVILTKQVPSAKVVETAITGAIDG-ISKQETQAMINNALRLYSQ 765

  Fly   788 DKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPNVQPGECWAFQG 852
            |:||:.||||||.||.||.|||:|:|.||:|.:|:|||||||.:.:|||.|.|::.||.||||:|
Frog   766 DRTGMADFALESGGGSILGTRCSETYGTKTALMSLFGIPLWYFSQSPRVVIQPDMYPGNCWAFKG 830

  Fly   853 FPGFLVLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPVLFGDYQFEDNG 917
            ..|:||::|:.::|.|.|::|||||||||.|.|.|||::|.|:||:.|..::..:.....::..|
Frog   831 TQGYLVVRLSRMIYPTAFSIEHIPKSLSPLGNITSAPKDFAVYGLDDEYQEDGQVLIRAVYDQEG 895

  Fly   918 ASLQYFAVQNLDIKRPYEIVELRIETNHGHPTYTCLYRFRVHGKP 962
            ..||.|.:.. :.|:|::||||||.:|.||..:|||||||.||.|
Frog   896 EPLQIFHIME-EYKKPFQIVELRIFSNWGHQDFTCLYRFRAHGTP 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
koi	NP_001260738.1	Sad1_UNC	827..962	CDD:285038	65/134 (49%)
sun1	XP_002941852.3	MRP	<129..>200	CDD:401368	6/24 (25%)
		MRP	<404..436	CDD:401368	13/45 (29%)
		SMC_prok_B	<543..738	CDD:274008	56/277 (20%)
		Sun2_CC2	708..762	CDD:408364	15/61 (25%)
		Sad1_UNC	805..939	CDD:400199	65/134 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4281
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000864
OrthoInspector	1	1.000	-	-		otm48566
Panther	1	1.100	-	-	O	PTHR12911
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2888
SonicParanoid	1	1.000	-	-		X471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.130