DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhB and SDH2

DIOPT Version :9

Sequence 1:	NP_477101.1	Gene:	SdhB / 35590	FlyBaseID:	FBgn0014028	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_013059.1	Gene:	SDH2 / 850685	SGDID:	S000003964	Length:	266	Species:	Saccharomyces cerevisiae

Alignment Length:	265	Identity:	174/265 - (65%)
Similarity:	206/265 - (77%)	Gaps:	13/265 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVARNQMRAISNGTAQLEQQAQPKEAQEPQIKKFEIYRWNPDNAGEKPYMQTYEVDLRECGPMVL 80
            ||.:..|...:...|          ...|::|.|::||||||....||::|:|:|||.:||||||
Yeast    13 LVTKKGMATATTAAA----------THTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVL 67

  Fly    81 DALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDINTSKSLKVYPLPHMYVVRD 145
            |||:|||:|.|.||||||||||||||||||||||.||||||.|||.|.||.||:||||||::|:|
Yeast    68 DALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKD 132

  Fly   146 LVPDMNNFYEQYRNIQPWLQRKNEAGEKKGKAQYLQSVEDRSKLDGLYECILCACCSTSCPSYWW 210
            ||||:.|||:||::|||:|||   :...|...:.|||:|||.|||||||||||||||||||||||
Yeast   133 LVPDLTNFYQQYKSIQPYLQR---SSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWW 194

  Fly   211 NAEKYLGPAVLMQAYRWIIDSRDENSAERLNKLKDPFSVYRCHTIMNCTRTCPKGLNPGRAIAEI 275
            |.|:|||||||||||||:|||||:.:..|...|.:..|:||||||||||||||||||||.|||||
Yeast   195 NQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEI 259

  Fly   276 KKLLS 280
            ||.|:
Yeast   260 KKSLA 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhB	NP_477101.1	PLN00129	6..279	CDD:215067	173/262 (66%)
SDH2	NP_013059.1	PLN00129	31..264	CDD:215067	169/235 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343849
Domainoid	1	1.000	181	1.000	Domainoid score	I698
eggNOG	1	0.900	-	-		E1_COG0479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2255
Inparanoid	1	1.050	376	1.000	Inparanoid score	I346
Isobase	1	0.950	-	0	Normalized mean entropy	S140
OMA	1	1.010	-	-		QHG54746
OrthoFinder	1	1.000	-	-		FOG0003194
OrthoInspector	1	1.000	-	-		otm46869
orthoMCL	1	0.900	-	-		OOG6_100664
Panther	1	1.100	-	-	LDO	PTHR11921
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R309
SonicParanoid	1	1.000	-	-		X1851
TreeFam	1	0.960	-	-
	16	15.740