Protein Alignment SdhB and SDHB

DIOPT Version :10

• Sequence 1: NP_477101.1
• Gene: SdhB / 35590
• FlyBaseID: FBgn0014028
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_002991.2
• Gene: SDHB / 6390
• HGNCID: 10681
• Length: 280
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 194/280 - (69%)
• Similarity: 234/280 - (83%)
• Gaps: 4/280 - (1%)

  Fly    10 LSRVGSLVARNQMRAISNGTA--QLEQQAQPKEAQEPQIKKFEIYRWNPDNAGEKPYMQTYEVDL 72
            ::.|.:|..|.::.|.:.|.|  |..:.||...|..|:||||.||||:||.||:||:||||||||
Human     1 MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDL 65

  Fly    73 RECGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDINTSKSLKVYPL 137
            .:|||||||||||||||:|.||||||||||||||||||||.|.|||||..:||.|.:|..|:|||
Human    66 NKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPL 130

  Fly   138 PHMYVVRDLVPDMNNFYEQYRNIQPWLQRKNEAGEKKGKAQYLQSVEDRSKLDGLYECILCACCS 202
            |||||::|||||::|||.||::|:|:|::|:|:.|  ||.|||||:|:|.|||||||||||||||
Human   131 PHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQE--GKQQYLQSIEEREKLDGLYECILCACCS 193

  Fly   203 TSCPSYWWNAEKYLGPAVLMQAYRWIIDSRDENSAERLNKLKDPFSVYRCHTIMNCTRTCPKGLN 267
            |||||||||.:||||||||||||||:|||||:.:.|||.||:||||:||||||||||||||||||
Human   194 TSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLN 258

  Fly   268 PGRAIAEIKKLLSGLASKPA 287
            ||:|||||||:::....|.|
Human   259 PGKAIAEIKKMMATYKEKKA 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhB	NP_477101.1	PLN00129	6..279	CDD:215067	192/270 (71%)
SDHB	NP_002991.2	PLN00129	5..271	CDD:215067	191/267 (72%)
		Interaction with SDHAF1. /evidence=ECO:0000269|PubMed:26749241	146..218		55/73 (75%)