DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhB and sdh2

DIOPT Version :9

Sequence 1:	NP_477101.1	Gene:	SdhB / 35590	FlyBaseID:	FBgn0014028	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_593530.2	Gene:	sdh2 / 2542842	PomBaseID:	SPAC140.01	Length:	275	Species:	Schizosaccharomyces pombe

Alignment Length:	280	Identity:	171/280 - (61%)
Similarity:	207/280 - (73%)	Gaps:	29/280 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLATEARQILSRVGSLVARNQMRAISNGTAQLEQQAQPKEAQEPQIKKFEIYRWNPDNAGEKPYM 65
            |:||||.                 ||..:|..:.|.:       .:|.||||||||:....||.:
pombe    23 MMATEAN-----------------ISATSANPQSQGE-------NLKTFEIYRWNPEKPEVKPKL 63

  Fly    66 QTYEVDLRECGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDINTSK 130
            |.|.|||.:|||||||||||||||.||||||||||||||||||||||.|:||||||..|. ..:|
pombe    64 QKYTVDLTKCGPMVLDALIKIKNEQDPTLTFRRSCREGICGSCAMNINGSNTLACICNIK-KDNK 127

  Fly   131 SLKVYPLPHMYVVRDLVPDMNNFYEQYRNIQPWLQRKNEAGEKKGKAQYLQSVEDRSKLDGLYEC 195
            ..|:|||||.::|:|||||:..||:||::|:||||..|...:|    ::.||..||:||||||||
pombe   128 PTKIYPLPHCFIVKDLVPDLTYFYKQYKSIEPWLQNDNIPKDK----EFYQSRADRAKLDGLYEC 188

  Fly   196 ILCACCSTSCPSYWWNAEKYLGPAVLMQAYRWIIDSRDENSAERLNKLKDPFSVYRCHTIMNCTR 260
            ||||||||||||||||:|:|||||||||||||||||||:.:|:||:.:::..|||||||||||.|
pombe   189 ILCACCSTSCPSYWWNSEEYLGPAVLMQAYRWIIDSRDQATAKRLDVMQNSMSVYRCHTIMNCAR 253

  Fly   261 TCPKGLNPGRAIAEIKKLLS 280
            |||||||||.|||::|.|::
pombe   254 TCPKGLNPGLAIAKVKALMA 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhB	NP_477101.1	PLN00129	6..279	CDD:215067	166/272 (61%)
sdh2	NP_593530.2	PLN00129	25..273	CDD:215067	170/276 (62%)
		Fer2_3	46..151	CDD:289830	73/105 (70%)
		Fer4_17	187..260	CDD:290268	58/72 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_COG0479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2255
Inparanoid	1	1.050	356	1.000	Inparanoid score	I471
OMA	1	1.010	-	-		QHG54746
OrthoFinder	1	1.000	-	-		FOG0003194
OrthoInspector	1	1.000	-	-		otm47321
orthoMCL	1	0.900	-	-		OOG6_100664
Panther	1	1.100	-	-	LDO	PTHR11921
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R309
SonicParanoid	1	1.000	-	-		X1851
TreeFam	1	0.960	-	-
	14	13.860