DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epac and RAPGEF5

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_036426.4	Gene:	RAPGEF5 / 9771	HGNCID:	16862	Length:	883	Species:	Homo sapiens

Alignment Length:	887	Identity:	302/887 - (34%)
Similarity:	456/887 - (51%)	Gaps:	105/887 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNR----MGWALRTLLVADNSSCL 215
            |::|.....:.:||......|.:|    ||.|  ..|||.....    .|.|||.:::...:..:
Human    61 LRSGLTLRRKRSAAGGRTLSRRIS----NPYL--EHTPSQIYGENSSCAGRALRNIIIVQAADLI 119

  Fly   216 KDR-KVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFL 279
            ||| .:.|...|.|. |:||||||:...|.|..|:.|.|:||.||:.|::..|::...|:|....
Human   120 KDRVNLKGFYRRSCV-GSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVF 183

  Fly   280 YRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKP--------SHERT 336
            |:|..||           ...|....|...|     :|.|....|:::...|        ||::.
Human   184 YQFSSDE-----------CSYLYCEFEREEE-----WQNGVKLLLQLVPLIPARGGICELSHQKI 232

  Fly   337 SEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVV 401
            .:..|...|.||      .|:::::|||:::...:|...|    ..|.:|....::.:..:..|.
Human   233 EDSEESSDEILV------RLTSAVQRELAAVIALKARKSA----IEQDEENNDKHVAVTEAESVP 287

  Fly   402 IHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDK------EHFNRILRDVEANT 460
            ....|.:..|:..|:.|::.|:..        |.:.|...|:.||      ||     :|.|..|
Human   288 DSQAGVMCKLQERDEIGRIELVQK--------LAKENYQFLQTDKKEQEKSEH-----QDDEVTT 339

  Fly   461 LRLQEHGKDVLVLERV-----AKQRGQ-HSAFKYTVMSGTPAKMLEHLLETRLGQSVGG--MDPF 517
            ::::|..:.||||::|     |...|. .|.::|.|:||||.|:|||||.....:.|..  .:..
Human   340 VQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETETL 404

  Fly   518 LDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAF 582
            |||||||:.|||....|...|..::....:   |..|:...:...|::|:..:.:|:...:....
Human   405 LDDFLLTYTVFMTTDDLCQALLRHYSAKKY---QGKEENSDVPRRKRKVLHLVSQWIALYKDWLP 466

  Fly   583 EEPSVCDFIEDLAAEVEAD----PDLNEETSIVHNVLTQMARYQED------RNQNAGQKWKLPP 637
            |:.....|::.:...|..|    |.|.:|......:|....|:..|      :|:....::.|..
Human   467 EDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKE 531

  Fly   638 NGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPE 702
            |     ......|.::|     ::|...||..:|:|.:::..:.:.|:.|....|:|:|.  ..|
Human   532 N-----WLQHRGTVTET-----EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQY--AEE 584

  Fly   703 DLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEIL- 766
            ||.||.:..:||:...:.||:.|...|..:||::|..||..|.|....|.|   |.....:.||
Human   585 DLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENE---ESQQRSMRILG 646

  Fly   767 -STKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTP 830
             :|.:||..:..|:|.||.::||.||:|.||.|...|:.||||.:.|:|.||||.|:.||::...
Human   647 MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCS 711

  Fly   831 SLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALI 895
            .|.|||.||:||||:||:||..:|||:|||:||||:..:||||.|||||||.||:|:|.|.|:|.
Human   712 QLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLT 776

  Fly   896 DPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCR 960
            |||.||:|||....|::||.||||||||||:||.||||||.||.||||||:||:|.|:||:|.||
Human   777 DPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCR 841

  Fly   961 SRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
            :...|  ..|||...|::||::...|||:|:.|..:|.::||
Human   842 TNQFG--DLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884	40/131 (31%)
		CAP_ED	352..463	CDD:237999	24/116 (21%)
		Crp	373..525	CDD:223736	47/165 (28%)
		RasGEF_N	489..594	CDD:279012	31/106 (29%)
		UBQ	665..>714	CDD:294102	14/48 (29%)
		RasGEF	766..1002	CDD:214539	131/237 (55%)
RAPGEF5	NP_036426.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9923
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143470at2759
OrthoFinder	1	1.000	-	-		FOG0000899
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103967
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2054
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850