Protein Alignment Epac and Rasgef1a

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001349032.1
• Gene: Rasgef1a / 70727
• MGIID: 1917977
• Length: 498
• Species: Mus musculus
• Alignment Length: 537
• Identity: 109/537 - (20%)
• Similarity: 199/537 - (37%)
• Gaps: 139/537 - (25%)

  Fly   492 SGTPAKMLEHLLETRLGQSVGGMDPFLD-----DFLLTHIVFMPVVQLVDELANYFHC-DAHEDA 550
            ||:...::|||:.|        :|.:.|     .|||:..||||...|:..:...  | :..:..
Mouse    55 SGSLEALMEHLVPT--------VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQI--CLEQRQQL 109

  Fly   551 QTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDF-IEDLAAEVEADPDLNEETSIVHNV 614
            :...::..:.:|..:::|.:::|..|..:         || .|.:.||::|         |.|.|
Mouse   110 EAGPEKAKLKSFSTKIVQLLKEWTEAFPY---------DFQDEKVMAELKA---------IAHRV 156

  Fly   615 LTQMARY--QEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTY---C 674
             ||...|  |...:|.                   |.|..|.:.:....::..:.......   .
Mouse   157 -TQCDEYLMQPRPSQE-------------------NGTVKKAIAQMIQSLLLSLAARSQLQELRE 201

  Fly   675 TLRFPMHTTAELIKA--CAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFV 737
            .||.|:.....::||  .||.|..|....:.|||.:..::          :.:....|:.....:
Mouse   202 KLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTH----------IELERVNSIRPEDLM 256

  Fly   738 SVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFG 802
            .:..|:|:   |....|..:         .||
Mouse   257 QIISHMDS---LDNHRCRGD---------MTK--------------------------------- 276

  Fly   803 KITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSN 867
              |.:|:.:...||.:...:.||:........|..::..||.:|..|....|.|:..|::.|::.
Mouse   277 --TFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNL 339

  Fly   868 MAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV-GKLQPP----------LIPFMPL 921
            ..|:||::||.|:  |..| |...|..:|||.|...||..: |..|..          :||...|
Mouse   340 SPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNL 401

  Fly   922 LLKDMTFAHEGNKTSL-DGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFR 985
            .:||:.|.|:.:...| :|.:||:|...:::.:........    :|.|..|.: :::||:.:..
Mouse   402 FVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQ----VECPFEKDK-KIQSYVLTAP 461

  Fly   986 VIDNQRVLTAMSQKVEP 1002
            :...:.:..|..:...|
Mouse   462 IYSEEALFIASFESEGP 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		RasGEF_N	489..594	CDD:459873	24/108 (22%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	13/74 (18%)
		RasGEF	766..1002	CDD:214539	53/247 (21%)
Rasgef1a	NP_001349032.1	REM	57..163	CDD:100121	30/134 (22%)
		RasGEF	234..428	CDD:459872	54/253 (21%)