Protein Alignment Epac and rgl2

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_005158441.1
• Gene: rgl2 / 65227
• ZFINID: ZDB-GENE-010131-1
• Length: 744
• Species: Danio rerio
• Alignment Length: 552
• Identity: 106/552 - (19%)
• Similarity: 183/552 - (33%)
• Gaps: 196/552 - (35%)

  Fly   463 LQEHGKDVLVLERVAKQ-------------RGQHSAFKYTVMSGTPAKMLEHLLET-RLGQSVGG 513
            :.|..:|.::...|.||             |.||      |.:||..|::.|||.: .:|.|
Zfish    73 VSEMEEDGIIYTVVVKQGPGSPTSPQSTAARSQH------VKAGTEEKLVLHLLHSFSMGDS--- 128

  Fly   514 MDPFLDDFLLTHIVFMPVVQLVDELANYFHC-------DAHEDAQTPEDREYIINFKKRVIQFMQ 571
              .|:..||.|:..|....:::|.|.    |       ::|.:::.        .|.|.|.....
Zfish   129 --SFISIFLSTYRSFTSTQRVLDILI----CRLENPPGESHSNSRQ--------MFNKAVCTVFS 179

  Fly   572 KWVMAVRHAAFEEPSVCDFIEDLAAEVEADPD-------LNEETSIVHNVLTQMARYQEDRNQNA 629
            .|             :.|:.||..:  .:||.       |....|....:.:::.|..|:.::..
Zfish   180 TW-------------MTDYPEDFRS--LSDPSRLLRLAPLLPTDSSGAEIKSRLLRIAEELSEKT 229

  Fly   630 GQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADK 694
                         .|.:..:.|:|.::.|.:...|     |.| ..|.||....||
Zfish   230 -------------LLSASLSDPTKGLLSPPNPSDF-----DAT-SVLGFPSSVIAE--------- 266

  Fly   695 LQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGV 759
             ||.|...||.|..|..:...|::...|                        .:.||..|
Zfish   267 -QLTRIETDLFLKLVPHHCLGSLWSQRD------------------------KKGQEGAC----- 301

  Fly   760 DIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQ---YW 821
                                    |:|.                  |.:..|.|..|.|.   .|
Zfish   302 ------------------------WSVR------------------ATIKQFNRLANAVTASCLW 324

  Fly   822 IVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRK 886
            :.| |.|    .:|..|:.|:|.:|..|:..:|.::.:|::..|.:..:.||::||::...:..|
Zfish   325 MTT-LKS----QQRARLLEKWISVAEACRTRKNFSSLYAILSALQSNPIHRLRKTWQETDREAVK 384

  Fly   887 IFQEFEALIDPSRNHRAYRV---------------------FVGKLQPPLIPFMPLLLKDMTFAH 930
            .::|...:.....|:...|.                     |.|......:|::.:.|:|:|...
Zfish   385 RYEELSDIFSEKDNYSQSRELLKEEGTSKFANHDTKINNRRFTGSCAQGTVPYLGIFLRDLTMLD 449

  Fly   931 EGNKTSLD-GLVNFEKMHMMAQTMRTIRFCRS 961
            ...|..|: |.:||:|.....:.:..||..:|
Zfish   450 TAVKDRLENGFINFDKRRREFEVIAQIRLLQS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999	106/552 (19%)
		Crp	373..525	CDD:223736	20/75 (27%)
		RasGEF_N	489..594	CDD:279012	24/112 (21%)
		UBQ	665..>714	CDD:294102	14/48 (29%)
		RasGEF	766..1002	CDD:214539	43/221 (19%)
rgl2	XP_005158441.1	REM	111..>190	CDD:100121	23/108 (21%)
		RasGEF	256..519	CDD:214539	60/312 (19%)
		UBQ	626..710	CDD:294102

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910