DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and RASGRF2

DIOPT Version :10

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_008840.1 Gene:RASGRF2 / 5924 HGNCID:9876 Length:1237 Species:Homo sapiens


Alignment Length:1128 Identity:217/1128 - (19%)
Similarity:397/1128 - (35%) Gaps:364/1128 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 TVVTKTTC----ELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLS 178
            |:|....|    |.:|...|....:.|...|.::.::.   |.|||   ::....|.|..|.|:|
Human   227 TIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYI---LVNGF---LRPLRMAASSKKPPIS 285

  Fly   179 PDHPNPALPITET---------PSPAMNRMGWALRTLLVAD------------------------ 210
            .|..:.....:||         .........|.  ||::||                        
Human   286 HDDVSSIFLNSETIMFLHEIFHQGLKARIANWP--TLILADLFDILLPMLNIYQEFVRNHQYSLQ 348

  Fly   211 -NSSCLKDRKVSGKLIRK------CA----------PGTELVDWLVNL------SPIVHTRAQAA 252
             .::|.::|... ||:::      |.          |..::..:::.|      :|..|...::.
Human   349 VLANCKQNRDFD-KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSL 412

  Fly   253 GMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIRE--ALSAL 315
            ...::.|||                 |.|...||...|               |:||:  |:..:
Human   413 EFAKSKLEE-----------------LSRVMHDEVSDT---------------ENIRKNLAIERM 445

  Fly   316 FQRGPDATL---------RMILRKPSHERTSEELELVFEELVHIAALSHL---STSIKRE-LSSI 367
            ...|.|..|         ..:::.||.||               ..||.:   |.|:|:| ....
Human   446 IVEGCDILLDTSQTFIRQGSLIQVPSVER---------------GKLSKVRLGSLSLKKEGERQC 495

  Fly   368 FVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVI-------------HGKGTVATLKTGDDFGK 419
            |:|..|     .|......|...::|..|.|..:|             ..||      :|..||.
Human   496 FLFTKH-----FLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKG------SGQVFGH 549

  Fly   420 L--ALINDAPRAA--TIVLKENNCHLLRVDK----EHFNRILRDVEAN---TLRLQEHGKDVLVL 473
            |  .::.:.|.||  |:||...:    |.:|    ...::.:.::..|   |:..:|:.| |.|.
Human   550 LDFKIVVEPPDAAAFTVVLLAPS----RQEKAAWMSDISQCVDNIRCNGLMTIVFEENSK-VTVP 609

  Fly   474 ERVAKQRGQHS-----AFKYTVMS--------GTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTH 525
            ..:......|.     .|..|:.|        .:..::||.|.:.|. .|:    .||:.||.|:
Human   610 HMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRF-LSI----DFLNTFLHTY 669

  Fly   526 IVFMPVVQLVDELAN----------------YFHCDAHEDAQTPEDR-EYIINFKKRVI--QFMQ 571
            .:|.....::.:|::                :|       |.:..:| |::::.|...:  :|..
Human   670 RIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFF-------ATSQNNRGEHLVDGKSPRLCRKFSS 727

  Fly   572 KWVMAV---------RHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQ 627
            ...:||         |..:...|        |.:::.|   |:..||......||......    
Human   728 PPPLAVSRTSSPVRARKLSLTSP--------LNSKIGA---LDLTTSSSPTTTTQSPAASP---- 777

  Fly   628 NAGQKWKLPPN-GQ-PICLFSGNATPSKT-------VIRPDDDIIFRV----------------- 666
                    ||: || |:.|..|.::|.::       |..|..|:..::                 
Human   778 --------PPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRA 834

  Fly   667 --------------------------------YCADHTYCTL----RFPMHTTAE---------- 685
                                            ..||:.:|::    .|.:.|.|.          
Human   835 GVESSPAADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNN 899

  Fly   686 ---------LIKACAADKL------QLNRGPEDLVL-VEVKSNG---ERSVFKDNDV-------- 723
                     :|:..|.:::      .:::..:|..| .|:|.|.   ...|.:|.|:        
Human   900 TERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAA 964

  Fly   724 -SIPTGLSLNGRLFVSVK-DHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAV 786
             :|...||.:.:..:.:| :.:..:|...:.||        .|.||..|||..|||.:..:|.::
Human   965 ANILRALSQDDQDDIHLKLEDIIQMTDCMKAEC--------FESLSAMELAEQITLLDHVIFRSI 1021

  Fly   787 HEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKE 851
            ...|.|...:.:....:.|..:....:.||::...:.:::::...:|.|...:.|::.:|..|:.
Human  1022 PYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRC 1086

  Fly   852 YQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLI 916
            ..|.|....:...|:..|:.||::||.|:..:.:.:..:.:..:......:..|..:....||.:
Human  1087 LHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151

  Fly   917 PFMPLLLKDMTFAHEG--NKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRS 979
            |::.:.|.|:.|..||  |.|. :|||||.||.|::..:|.||..:..|..:: ..||    |..
Human  1152 PYLGMYLTDLAFIEEGTPNFTE-EGLVNFSKMRMISHIIREIRQFQQTSYRID-HQPK----VAQ 1210

  Fly   980 YISSFRVIDNQRVLTAMSQKVEP 1002
            |:....:|.::..|..:|.|:||
Human  1211 YLLDKDLIIDEDTLYELSLKIEP 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 CAP_ED 36..146 CDD:237999 8/31 (26%)
DEP_Epac 199..330 CDD:239884 29/188 (15%)
CAP_ED 352..463 CDD:237999 31/138 (22%)
RasGEF_N 489..594 CDD:459873 24/140 (17%)
Ubl1_cv_Nsp3_N-like 652..>722 CDD:475130 18/158 (11%)
RasGEF 766..1002 CDD:214539 59/237 (25%)
RASGRF2NP_008840.1 PH_RasGRF1_2 19..158 CDD:270081
RhoGEF 247..428 CDD:214619 33/206 (16%)
PH 480..588 CDD:214574 27/122 (22%)
RasGEF_N 638..>686 CDD:459873 12/52 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..809 23/121 (19%)
Regulates proteasomal degradation. /evidence=ECO:0000250 744..752 1/15 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..873 2/43 (5%)
REM <901..972 CDD:470601 11/70 (16%)
RasGEF 998..1234 CDD:214539 62/242 (26%)
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1099..1128 7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

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