DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and RALGDS

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_006257.1 Gene:RALGDS / 5900 HGNCID:9842 Length:914 Species:Homo sapiens


Alignment Length:677 Identity:128/677 - (18%)
Similarity:235/677 - (34%) Gaps:179/677 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   444 VDKEHFNRILRDVEANTLRLQEHG-----------KDVLVLERVAKQRGQHSAFKYTVMSGTPAK 497
            :.:|..|.::..:....::|...|           :..|.|....|.|        ||.:||..|
Human    67 IGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVR--------TVKAGTLEK 123

  Fly   498 MLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDEL-ANYFHCDA--------------H 547
            ::|||:....|..:.    ::..||.|:..|....|::|.| ..|..|||              .
Human   124 LVEHLVPAFQGSDLS----YVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSD 184

  Fly   548 EDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDF--IEDLAAEVEADPDLNEETSI 610
            ||. .|:|:     .|..:...:..|:........:.|   ||  ::.|.|.|:.:...::....
Human   185 EDG-GPQDQ-----LKNAISSILGTWLDQYSEDFCQPP---DFPCLKQLVAYVQLNMPGSDLERR 240

  Fly   611 VHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCT 675
            .|.:|.|:...:             |...:|..|   :..|:   ::|..::...:..|      
Human   241 AHLLLAQLEHSE-------------PIEAEPEAL---SPVPA---LKPTPELELALTPA------ 280

  Fly   676 LRFPMHTTAEL--------------IKACAADKLQLNRGPEDLV--------LVEVKSNGERSVF 718
             |.|....|..              ::...|...:|.:.||..|        .:|::...|:...
Human   281 -RAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPA 344

  Fly   719 KDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLF 783
            ....:.:....:....|..|....:.|...|.|:: |      .|.:.....:|...||.:.:||
Human   345 PSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEK-P------HLLVFPPDLVAEQFTLMDAELF 402

  Fly   784 WAVHEYELLYHTFG-----RHHFGK--ITANLDVFLRRFNEVQYWIVTELVSTPSLS--KRVGLV 839
            ..|    :.||..|     |...||  :...:...:.:||.|...::|..:...|..  .|..:|
Human   403 KKV----VPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVV 463

  Fly   840 RKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAY 904
            ..:|::|..|:..:|.::.:|::..|.:.::.||::|||.:.....:|||:...:.....|:...
Human   464 EHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLS 528

  Fly   905 RVFVGK----------LQPP--------------LIPFMPLLLKDMTFAHEGNKTSLDG-LVNFE 944
            |..:.|          :.|.              .:|::...|.|:.......|..|.| |:|||
Human   529 RELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFE 593

  Fly   945 KMHMMAQTMRTIRF----CRSRSLG--------------------------LEPPSPKSEGEVRS 979
            |.....:.:..|:.    |.:.|:.                          |||||       .|
Human   594 KRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPS-------ES 651

  Fly   980 YISSFRVIDNQRVLTAMSQKVEPTRKL 1006
            ..::.|...|..::...|.:..|:.:|
Human   652 ASNTLRTKKNTAIVKRWSDRQAPSTEL 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736
CAP_ED 36..146 CDD:237999
DEP_Epac 199..330 CDD:239884
CAP_ED 352..463 CDD:237999 2/18 (11%)
Crp 373..525 CDD:223736 19/91 (21%)
RasGEF_N 489..594 CDD:279012 29/121 (24%)
UBQ 665..>714 CDD:294102 10/70 (14%)
RasGEF 766..1002 CDD:214539 60/299 (20%)
RALGDSNP_006257.1 RasGEFN 112..248 CDD:214571 36/156 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..365 12/91 (13%)
RasGEF 382..644 CDD:238087 52/265 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..689 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..776
RalGDS_RA 798..883 CDD:176351
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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