Protein Alignment Epac and RGL2

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_024302273.1
• Gene: RGL2 / 5863
• HGNCID: 9769
• Length: 816
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 102/535 - (19%)
• Similarity: 173/535 - (32%)
• Gaps: 182/535 - (34%)

  Fly   492 SGTPAKMLEHLLETRLGQSVGGMD-PFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPED 555
            :||...::.|||:||    ..|.| .|:..||.||..|.
Human    94 AGTLEALVRHLLDTR----TSGTDVSFMSAFLATHRAFT-------------------------- 128

  Fly   556 REYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADP--DLNEETSIVHNVL-TQ 617
                                       ..|::...:.|....:|:.|  :|...|.:..:|| |.
Human   129 ---------------------------STPALLGLMADRLEALESHPTDELERTTEVAISVLSTW 166

  Fly   618 MARYQEDRNQNA-GQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMH 681
            :|.:.||....| ||..:|.                                        .|.:.
Human   167 LASHPEDFGSEAKGQLDRLE----------------------------------------SFLLQ 191

  Fly   682 TTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDAL 746
            |      ..||.| .:..|..||:      ...||........:|..|:|.|
Human   192 T------GYAAGK-GVGGGSADLI------RNLRSRVDPQAPDLPKPLALPG------------- 230

  Fly   747 TQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFG---RHHFGKITANL 808
                  :.|.:..|:  .:.....||..:||.:.:||..:...:.|...:|   |.....:..::
Human   231 ------DPPADPTDV--LVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSV 287

  Fly   809 DVFLRRFNEVQYWIVTELVSTPSLS--------------KRVGLVRKFIKLAAYCKEYQNLNAFF 859
            ...:.:||:|...:|:.::...|..              :|..|:.|:|::|..|:..:|.::.:
Human   288 RATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVY 352

  Fly   860 AVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNH---RAYRVFVGKLQPPL------ 915
            |||..|.:..:.||:..|.:......::|.....:.....|:   |...|...|||.||
Human   353 AVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417

  Fly   916 -----------IPFMPLLLKDMTFAHEGNKTSLD-GLVNFEKMHMMAQTMRTIRFCRSRSLGLE- 967
                       :|::...|||:......:|..|: |.:||:|       .|.:........||.
Human   418 APRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDK-------RRKVSGVSGLDAGLPY 475

  Fly   968 PPSPKSEGEVRSYIS 982
            |.|.|..|:.:..:|
Human   476 PCSRKGRGKSQGSLS 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	12/33 (36%)
		RasGEF_N	489..594	CDD:279012	16/102 (16%)
		UBQ	665..>714	CDD:294102	8/48 (17%)
		RasGEF	766..1002	CDD:214539	55/256 (21%)
RGL2	XP_024302273.1	RasGEFN	90..212	CDD:214571	39/227 (17%)
		RasGEF	239..552	CDD:214539	55/261 (21%)
		RalGDS_RA	687..772	CDD:176351

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810