DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and RGL3

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_001155088.2 Gene:RGL3 / 57139 HGNCID:30282 Length:716 Species:Homo sapiens


Alignment Length:539 Identity:112/539 - (20%)
Similarity:188/539 - (34%) Gaps:162/539 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 LETRLGQSVGG---MDP-FLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFK 563
            ||..:|:.|.|   .|| |:..||.|:..|:|...|:..|............:..:.....::|.
Human    74 LERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFN 138

  Fly   564 KR---VIQFMQKWVMAVRHAAFEEP------SVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMA 619
            |.   |:..:..|:........:.|      ||..|: ..||...|:....|:  ::.:.|.:..
Human   139 KNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFL-GWAAPGSAEAQKAEK--LLEDFLEEAE 200

  Fly   620 RYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTA 684
            |.||   :...|.|..||                                       |....:..
Human   201 REQE---EEPPQVWTGPP---------------------------------------RVAQTSDP 223

  Fly   685 ELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQL 749
            :..:|||.::..|                           :|.|..|           ||     
Human   224 DSSEACAEEEEGL---------------------------MPQGPQL-----------LD----- 245

  Fly   750 QEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFG-RHHFGKITANLDV--F 811
                            .|..|:|..:||.:.:||..|..||.|...:. |...|...|:..|  .
Human   246 ----------------FSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRAT 294

  Fly   812 LRRFNEVQYWIVTELVSTPSLS--KRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQ 874
            :.:||.|...::..::..|.|:  :|...:.|:|::|..|:|.:|.::..|::..|.:..:.||:
Human   295 VAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLK 359

  Fly   875 QTWEKIP----SKFRKIFQEFEALIDPSRNHRAYRVFV--------------------GKLQPPL 915
            ::|..:.    |.|||:.|.|    ....||.:.|..:                    .|..|..
Human   360 RSWGAVSREPLSTFRKLSQIF----SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420

  Fly   916 IPFMPLLLKDMTFAHEGNKTSLDG-LVNFEK----MHMMAQTMRTIRFCRSRSLGLEPP------ 969
            :|::...|.|:..........|:| |:||||    ..::|:..:..|.|:|.:|...||      
Human   421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALH 485

  Fly   970 SPKSEGEVRSYISSFRVID 988
            :.....|.:||..| |||:
Human   486 AQNQLTEEQSYRLS-RVIE 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736
CAP_ED 36..146 CDD:237999
DEP_Epac 199..330 CDD:239884
CAP_ED 352..463 CDD:237999
Crp 373..525 CDD:223736 10/25 (40%)
RasGEF_N 489..594 CDD:279012 23/103 (22%)
UBQ 665..>714 CDD:294102 5/48 (10%)
RasGEF 766..1002 CDD:214539 67/263 (25%)
RGL3NP_001155088.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..54
REM 74..196 CDD:100121 27/124 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..234 11/77 (14%)
RasGEF 243..505 CDD:214539 70/298 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..419 1/21 (5%)
Interaction with HRAS, MRAS and RIT1. /evidence=ECO:0000250 618..713
RalGDS_RA 619..704 CDD:176351
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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