Protein Alignment Epac and sos1

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001428581.1
• Gene: sos1 / 556286
• ZFINID: ZDB-GENE-070209-128
• Length: 1317
• Species: Danio rerio
• Alignment Length: 745
• Identity: 159/745 - (21%)
• Similarity: 264/745 - (35%)
• Gaps: 197/745 - (26%)

  Fly   297 QAEDLG-AANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSH----- 355
            :.:|:| ..||.|.|           .||..:..|  |||..    .:|:.|:.....:|
Zfish   433 EGKDIGQCCNEFIME-----------GTLTRVGAK--HERHI----FLFDGLMICCKSNHGQPRL 480

  Fly   356 -LSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGK 419
             .:::.:..|...| |....|.......:|:...::.|:||....||...|.  |..|.|   ..
Zfish   481 PGASAAEYRLKEKF-FMRKVQINDKDDKEGEYRHAFEIILKDGNSVVFSAKS--AEEKNG---WM 539

  Fly   420 LALINDAPRAA------TIVLKENNCHLLRVDKEHFNRILR-DVEANTLRLQEHGKDVLVLERVA 477
            .|||:...|:.      |.:|:|.....:|:......|... |.|.|          |:..|.|.
Zfish   540 AALISLQYRSTLERMLDTAMLQEEKEEQMRLPGAQLYRFAEPDSEEN----------VVFEENVQ 594

  Fly   478 KQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDP-FLDDFLLTHIVFMPVVQLVDELANY 541
            .:.|..     .:.:||..|::|.|......      || |:..||.|:..|....:|:|.|...
Zfish   595 SKSGIP-----IIKAGTVLKLIERLTFHMYA------DPNFVRTFLTTYRSFCKPQELLDLLIER 648

  Fly   542 FHCD----------AHEDAQTPEDREYIINFKKRVIQFMQKWVMAV-RHAAFEEPSVCDFIEDLA 595
            |...          |.|:...|...| :..|:|..:|.:|..|:.| ||          ::|...
Zfish   649 FEIPEPKPTEADQMALENGDQPLSAE-LKRFRKEFVQPVQLRVLNVCRH----------WVEHHF 702

  Fly   596 AEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDD 660
            .:.|.|..|          |.::..:.......|.:||
Zfish   703 YDFERDAQL----------LRRLEEFIGTVRGKAMRKW--------------------------- 730

  Fly   661 DIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSI 725
                                   .|.|......|.|          .:...:.....|:.:..:|
Zfish   731 -----------------------VESITKIIQRKKQ----------AQASGSSHNITFESSPPAI 762

  Fly   726 PTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYE 790
            ...|...|::               ||        .||..|...|:|..:||.|.|.:.||...|
Zfish   763 EWHLCRAGQV---------------EQ--------FDLMTLHPIEIARQLTLLESDFYRAVQPSE 804

  Fly   791 LLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNL 855
            |:...:.:......:.||...:|....:..|:...:|.|.::.:||.:|.:.|::....:|..|.
Zfish   805 LVGSVWTKEDKEINSPNLLRMIRHTTNLTLWLEKCIVETENVEERVSVVSRIIEILQVFQELNNF 869

  Fly   856 NAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQ---PPLIP 917
            |....||..:::..|.||..|:|:|||:.|||.:|...|   |.:|  |:.::.||:   ||.:|
Zfish   870 NGVLEVVSAMNSSPVYRLDHTFEQIPSRQRKILEEAHEL---SEDH--YKKYLAKLRSINPPCVP 929

  Fly   918 FMPLLLKDMTFAHEGNKTSL----DGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVR 978
            |..:.|.::....|||...|    ..|:||.|...:|:....|:..::     :|...:.|.::|
Zfish   930 FFGIYLTNILKTEEGNPDFLKRHGTELINFSKRRKVAEITGEIQQYQN-----QPYCLRVENDIR 989

  Fly   979 SYISSFRVIDNQR------VLTAMSQKVEP 1002
            .:..:...:::..      .|...|.::||
Zfish   990 KFFENLNPMEDMMEKEFTDYLFNKSLEIEP 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884	8/33 (24%)
		CAP_ED	352..463	CDD:237999	27/123 (22%)
		RasGEF_N	489..594	CDD:459873	29/116 (25%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	5/69 (7%)
		RasGEF	766..1002	CDD:214539	64/248 (26%)
sos1	NP_001428581.1	None