Protein Alignment Epac and RAPGEFL1

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_057423.2
• Gene: RAPGEFL1 / 51195
• HGNCID: 17428
• Length: 662
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 192/530 - (36%)
• Similarity: 298/530 - (56%)
• Gaps: 38/530 - (7%)

  Fly   493 GTPAKMLEHLLETRLGQSVGG-------MDPFLDDFLLTHIVFMPVVQLVDELANYF-HCDAHED 549
            |.|.:. ||||...|.:..||       .|..|||.:|||.:|:|..:.:.||..|| .....|.
Human   146 GAPERP-EHLLNRVLERLAGGATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEG 209

  Fly   550 AQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPD----LNEETSI 610
               ||.    :..|:..:..:..::...:....||......|:||...:..|..    |.|:|..
Human   210 ---PEG----LGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLR 267

  Fly   611 VHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFS-----GNATPSKTVIRPDDDIIFRVYCAD 670
            :|.::..:.....:.||        ||:.|...||.     .:...::...|..|:|..|||..|
Human   268 LHQLVETVELKIPEENQ--------PPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPD 324

  Fly   671 HTYCTLRFPMHTTAELIKACAADKLQLNRGP----EDLVLVEVKSNGERSVFKDNDVSIPTGLSL 731
            |:|.|:|..:..:.:.|.....:|||.:..|    :.|:||.|.|:||:.:.:..:..:.|.|.:
Human   325 HSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGI 389

  Fly   732 NGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTF 796
            |..||...:|..:||..|.|:...:.| |.::..:..:::|.|:|.|.|:||..|||.|.:.:.|
Human   390 NSHLFACTRDSYEALVPLPEEIQVSPG-DTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVF 453

  Fly   797 GRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAV 861
            ......:.||||::.|:|.:||.:|:.||::...:..||..|::||||:||.||:.|:|.:|:||
Human   454 HGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAV 518

  Fly   862 VMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDM 926
            ||||.|.|||||:.||||:|.||:.:|::||.|.||.|||::||..:.|::||:|||:||:|||:
Human   519 VMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDL 583

  Fly   927 TFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQR 991
            ||.|||:||.:|||||.||:|.:|:.:||||..|||.|.|:..:..:..:.::|:..|:|||||.
Human   584 TFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQN 648

  Fly   992 VLTAMSQKVE 1001
            :|..:|.|:|
Human   649 LLFELSYKLE 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	14/38 (37%)
		RasGEF_N	489..594	CDD:279012	29/108 (27%)
		UBQ	665..>714	CDD:294102	18/52 (35%)
		RasGEF	766..1002	CDD:214539	114/236 (48%)
RAPGEFL1	NP_057423.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..149		1/2 (50%)
		RasGEF	420..658	CDD:214539	113/237 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143470at2759
OrthoFinder	1	1.000	-	-		FOG0000899
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920