DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epac and Sos

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	779	Identity:	148/779 - (18%)
Similarity:	267/779 - (34%)	Gaps:	266/779 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 ILRKPSHERTSEELELVFE------------ELVHIAALSHLSTSIKRELS--SIFVFEAHAQAG 377
            :.|:.:.||| .||::..|            |.:...:||.|.:. ||..|  .:|:|:
  Fly   450 VRRQLAIERT-RELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSG-KRIWSERKVFLFD------ 506

  Fly   378 TILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDD-------FGKLALIND---------- 425
                       ...:|.|.:..     |.|.:...|..|       |.:...|||
  Fly   507 -----------GLMVLCKANTK-----KQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNS 555

  Fly   426 ---APR-AATIVLKENNCH---------LLRVDK----EHFNRILRDVE-ANTLRL--------- 463
               ||| ...|||...|..         |:.:.|    .|.:.||:|:| .:.||:
  Fly   556 FELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFA 620

  Fly   464 -QEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIV 527
             .:.|.::::.||       .||....:...|..|::|     ||...:.....|:..||.|:..
  Fly   621 VPDSGDNIVLEER-------ESAGVPMIKGATLCKLIE-----RLTYHIYADPTFVRTFLTTYRY 673

  Fly   528 FMPVVQLVDELANYF----------------------------HCDAHEDAQTPEDREYIINFKK 564
            |....||:..|...|                            |.::|.:......:||:...:.
  Fly   674 FCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQF 738

  Fly   565 RVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNA 629
            ||:..::.||         :....||        |.||.|          |.::..:.|..|..:
  Fly   739 RVLNVLRHWV---------DHHFYDF--------EKDPML----------LEKLLNFLEHVNGKS 776

  Fly   630 GQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADK 694
            .:||                                                          .|.
  Fly   777 MRKW----------------------------------------------------------VDS 783

  Fly   695 LQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVS-------VKDHLDALTQLQEQ 752
            :        |.:|:.|:..|:|               |.::..:       ::.||..
  Fly   784 V--------LKIVQRKNEQEKS---------------NKKIVYAYGHDPPPIEHHLSV------- 818

  Fly   753 ECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNE 817
              |.:  :|.|..|...|||..:||.|::::..|...||:...:.:......:.||...::....
  Fly   819 --PND--EITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTN 879

  Fly   818 VQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPS 882
            |..||...:....:..:|:.::::.|::.....|..|.|...::|..:...:|.||:.|::.:|.
  Fly   880 VTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPE 944

  Fly   883 KFRKIFQEFEALIDPSRNH-RAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFE 944
            ::||..:|...|.|   :| :.|:..:..:.||.:||....|.::....|||...|..  |:||.
  Fly   945 RYRKFLEECRELSD---DHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFS 1006

  Fly   945 KMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSY---ISSFRVIDNQRV---LTAMSQKVEP 1002
            |...:|:.:..|:..::     :|.....|..:|.:   :..|..:.::::   |...|.::||
  Fly  1007 KRRKVAEIIGEIQQYQN-----QPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEP 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884	0/2 (0%)
		CAP_ED	352..463	CDD:237999	33/147 (22%)
		Crp	373..525	CDD:223736	39/196 (20%)
		RasGEF_N	489..594	CDD:279012	24/132 (18%)
		UBQ	665..>714	CDD:294102	4/48 (8%)
		RasGEF	766..1002	CDD:214539	54/244 (22%)
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963	27/132 (20%)
		PH	482..587	CDD:278594	26/127 (20%)
		RasGEFN	637..791	CDD:214571	36/251 (14%)
		RasGEF	825..1062	CDD:238087	55/244 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940