Protein Alignment Epac and Sos

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 148/779 - (18%)
• Similarity: 267/779 - (34%)
• Gaps: 266/779 - (34%)

  Fly   327 ILRKPSHERTSEELELVFE------------ELVHIAALSHLSTSIKRELS--SIFVFEAHAQAG 377
            :.|:.:.||| .||::..|            |.:...:||.|.:. ||..|  .:|:|:
  Fly   450 VRRQLAIERT-RELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSG-KRIWSERKVFLFD------ 506

  Fly   378 TILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDD-------FGKLALIND---------- 425
                       ...:|.|.:..     |.|.:...|..|       |.:...|||
  Fly   507 -----------GLMVLCKANTK-----KQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNS 555

  Fly   426 ---APR-AATIVLKENNCH---------LLRVDK----EHFNRILRDVE-ANTLRL--------- 463
               ||| ...|||...|..         |:.:.|    .|.:.||:|:| .:.||:
  Fly   556 FELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFA 620

  Fly   464 -QEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIV 527
             .:.|.::::.||       .||....:...|..|::|     ||...:.....|:..||.|:..
  Fly   621 VPDSGDNIVLEER-------ESAGVPMIKGATLCKLIE-----RLTYHIYADPTFVRTFLTTYRY 673

  Fly   528 FMPVVQLVDELANYF----------------------------HCDAHEDAQTPEDREYIINFKK 564
            |....||:..|...|                            |.::|.:......:||:...:.
  Fly   674 FCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQF 738

  Fly   565 RVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNA 629
            ||:..::.||         :....||        |.||.|          |.::..:.|..|..:
  Fly   739 RVLNVLRHWV---------DHHFYDF--------EKDPML----------LEKLLNFLEHVNGKS 776

  Fly   630 GQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADK 694
            .:||                                                          .|.
  Fly   777 MRKW----------------------------------------------------------VDS 783

  Fly   695 LQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVS-------VKDHLDALTQLQEQ 752
            :        |.:|:.|:..|:|               |.::..:       ::.||..
  Fly   784 V--------LKIVQRKNEQEKS---------------NKKIVYAYGHDPPPIEHHLSV------- 818

  Fly   753 ECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNE 817
              |.:  :|.|..|...|||..:||.|::::..|...||:...:.:......:.||...::....
  Fly   819 --PND--EITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTN 879

  Fly   818 VQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPS 882
            |..||...:....:..:|:.::::.|::.....|..|.|...::|..:...:|.||:.|::.:|.
  Fly   880 VTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPE 944

  Fly   883 KFRKIFQEFEALIDPSRNH-RAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFE 944
            ::||..:|...|.|   :| :.|:..:..:.||.:||....|.::....|||...|..  |:||.
  Fly   945 RYRKFLEECRELSD---DHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFS 1006

  Fly   945 KMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSY---ISSFRVIDNQRV---LTAMSQKVEP 1002
            |...:|:.:..|:..::     :|.....|..:|.:   :..|..:.::::   |...|.::||
  Fly  1007 KRRKVAEIIGEIQQYQN-----QPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEP 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884	0/2 (0%)
		CAP_ED	352..463	CDD:237999	33/147 (22%)
		RasGEF_N	489..594	CDD:459873	24/132 (18%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	6/69 (9%)
		RasGEF	766..1002	CDD:214539	54/244 (22%)
Sos	NP_476597.2	HFD_SOS1_rpt1	68..145	CDD:467039
		HFD_SOS1_rpt2	153..227	CDD:467040
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963	27/132 (20%)
		RasGEFN	637..791	CDD:214571	36/251 (14%)
		RasGEF	825..1062	CDD:238087	55/244 (23%)
		PHA03247	<1197..1502	CDD:223021