DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Epac and PDZ-GEF

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster


Alignment Length:1105 Identity:230/1105 - (20%)
Similarity:388/1105 - (35%) Gaps:435/1105 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   306 EHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVF 370
            |.:.|::.:|..|  || :|..|.|...||:.|::|::.|....:.|.::::.:::|.|.|:.||
  Fly    85 EDLAESMDSLTVR--DA-VRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVF 146

  Fly   371 EAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLK 435
            ....:|||::.:.|:|..||.:|:.|:|::. |..|:...|:.||.||.|..::.......:..|
  Fly   147 AVVDKAGTVVMSDGEELDSWSVLINGAVEIE-HANGSREELQMGDSFGILPTMDKLYHRGVMRTK 210

  Fly   436 ENNCHLLRVDKEHFNRILRDVEANTLRLQ-EHGKDVLVLE-RVAKQRGQHSAFK----------- 487
            .::|..:.:.:..:.||....|.||.|.: |:|..|:|.| |.....|..||..           
  Fly   211 CDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASL 275

  Fly   488 -----YTVMSGTPAKMLEHLLETRLGQSVGGMDP-FLDDFLLTHIVFMPVVQ-LVDELANYF--- 542
                 :.|:.|||.::|:.|:|..     ...|| :::||||||.:|:...| :..:|.::|   
  Fly   276 NMKRGHVVIRGTPERLLQQLVEEN-----SMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLE 335

  Fly   543 HCDAHEDAQ-------------------------------------------------------- 551
            ..|||:..:                                                        
  Fly   336 QVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAK 400

  Fly   552 --------TPEDREYIINFK--------------------------------------------- 563
                    |...|:..:||:                                             
  Fly   401 ARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHE 465

  Fly   564 -----------KRVIQFM-----------------QKWVMAVRHAAFEEPS-------------- 586
                       ||.::.:                 ::.:.|:.|......|              
  Fly   466 VNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVR 530

  Fly   587 ----VC-----------DFIEDLAAEVEAD-------------------------PDLNEETSIV 611
                :|           |...|..:.|.|.                         |.::...::.
  Fly   531 SPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMA 595

  Fly   612 HNVLTQMARY----------------QED------------------------RNQNAGQ----- 631
            .|.:.|:.:.                |:|                        ..||.|.     
  Fly   596 SNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDS 660

  Fly   632 --------KWKLPP------------NGQPICLFSG----------------------------- 647
                    |.||..            ||   |..||                             
  Fly   661 SDTLLNDPKSKLSAVSSCSSSTQSSING---CTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGG 722

  Fly   648 -----------------------NATPSKTVIRPD-DDIIFRVYCADHTYCTLRFPMHTTAELIK 688
                                   |:|.|.  :.|| .|.:.:||.||.|...:.....|||..:.
  Fly   723 GRLQVNYLNAHIHRPSAASTLTTNSTQSH--LLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVV 785

  Fly   689 ACAADKLQLNRGPEDLVLVEVKSNGERSVFK-----DNDVSIPTGLSLNGRLFVSVKDHLDALTQ 748
            .....:..::....:..|.|| |.|:..:.|     |...::...:|...|.::.:.|..:.|. 
  Fly   786 MLTLQEFGIHDPSSNFSLCEV-SVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLV- 848

  Fly   749 LQEQECPTEGVDIDLEI----------LSTKELAYHITLFEWDLFWAVHEYELLYHTFG-RHHFG 802
                  |.|   :.||:          |:..|||..:||.::..|..:...|.:...|. |..:|
  Fly   849 ------PDE---LALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYG 904

  Fly   803 KITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSN 867
              ...|..|....|...:|:|:|:.:..::.:|:.:|::|||:|.:|||.:|.|:.||:|.||.:
  Fly   905 --VPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGH 967

  Fly   868 MAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGK---LQPPLIPFMPLLLKDMTFA 929
            .|||||:|||||:|||::::|.:.:.|:|||||...||..|..   .|.|:|||.|::.||:||.
  Fly   968 GAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFI 1032

  Fly   930 HEGNKTSLDGLVNFEKMHMMAQTMRTI-RFCRS-------------------------------- 961
            |.||.|.:|||:||||:.|:|:.:|.: ..|.|                                
  Fly  1033 HLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNA 1097

  Fly   962 -----------------RSLGLEPPSPKSEGE-------VRSYISSFRVIDNQRVLTAMSQKVEP 1002
                             |......|:||...|       |::|::|.:::.::.:|...|.:.||
  Fly  1098 AAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162

  Fly  1003  1002
              Fly  1163  1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736
CAP_ED 36..146 CDD:237999
DEP_Epac 199..330 CDD:239884 8/23 (35%)
CAP_ED 352..463 CDD:237999 31/110 (28%)
Crp 373..525 CDD:223736 48/170 (28%)
RasGEF_N 489..594 CDD:279012 33/275 (12%)
UBQ 665..>714 CDD:294102 12/48 (25%)
RasGEF 766..1002 CDD:214539 92/296 (31%)
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 31/109 (28%)
RasGEFN 279..400 CDD:214571 22/125 (18%)
PDZ_signaling 404..494 CDD:238492 6/89 (7%)
DegQ <422..494 CDD:223343 2/71 (3%)
PDZ_GEF_RA 757..841 CDD:176380 18/84 (21%)
RasGEF 871..1050 CDD:279011 76/180 (42%)
Rhomboid_SP 1252..>1357 CDD:289371
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467918
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR23113
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

Return to query results.
Submit another query.