DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Epac and Rapgefl1

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	XP_008766424.1	Gene:	Rapgefl1 / 303515	RGDID:	1563269	Length:	663	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	196/544 - (36%)
Similarity:	300/544 - (55%)	Gaps:	65/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 GTPAKMLEHLLETRLGQSVGG--------MDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHED 549
            |.|.:. ||||...|.:..||        .|..|||.:|||.:|:|..:.:.||..||  ...::
  Rat   146 GAPERP-EHLLNRVLERLAGGTTRDSSSASDILLDDIVLTHSLFLPTEKFLQELHQYF--VQSKN 207

  Fly   550 AQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEAD----PDLNEETSI 610
            .:.||.    :..|:..:..:..::...:....||......|::|...:..|    .||.|:|..
  Rat   208 VEGPEG----LGRKQACLALLLHFLDTYQGLLQEEEGAGHIIKELYLLIMKDESLYQDLREDTLR 268

  Fly   611 VHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTV-------------------I 656
            :|.::..:             :.|:|...||         |||.|                   .
  Rat   269 LHQLVETV-------------ELKIPEESQP---------PSKQVKPLFRHFRRIDSCLQTRVAF 311

  Fly   657 RPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGP---ED-LVLVEVKSNGERSV 717
            |..|:|..|||..||:|.|:|..:..:.:.|.....:|||.:..|   || |:||.|.|:||:.:
  Rat   312 RGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAEREDALILVAVASSGEKVL 376

  Fly   718 FKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDL 782
            .:..:..:.|.|.:|..||...:|..:||..|.|:...:.| |.::..:..:::|.|:|.|.|:|
  Rat   377 LQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEIQASPG-DTEIHRVEPEDVANHLTAFHWEL 440

  Fly   783 FWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAA 847
            |..|||.|.:.:.|......:.||||::.|:|.:||.:|:.||::...:..|||.|::||||:||
  Rat   441 FRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAA 505

  Fly   848 YCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQ 912
            .||:.|:|.:|:||||||.|.|||||:.||||:|.||:.:|::||:|.||.|||::||..:.|::
  Rat   506 ICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFESLTDPCRNHKSYREVISKMK 570

  Fly   913 PPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEV 977
            ||||||:||:|||:||.|||:||.:|||||.||:|.:|:.:||||..|||.|.|:..:.....:.
  Rat   571 PPLIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQT 635

  Fly   978 RSYISSFRVIDNQRVLTAMSQKVE 1001
            ::|:..|:|||||..|..:|.|:|
  Rat   636 KAYVRQFQVIDNQNHLFELSYKLE 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	14/39 (36%)
		RasGEF_N	489..594	CDD:279012	28/108 (26%)
		UBQ	665..>714	CDD:294102	20/52 (38%)
		RasGEF	766..1002	CDD:214539	116/236 (49%)
Rapgefl1	XP_008766424.1	RasGEF	421..659	CDD:214539	115/237 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143470at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010